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Target Report Card

Target Name and Classification

Target ID CHEMBL2878
Preferred Name Histone deacetylase 6
Synonyms HD6 | Hdac6 | Histone deacetylase 6 | Histone deacetylase mHDA2
Organism Mus musculus
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iib

Target Components

Component Description Relationship Accession
Histone deacetylase 6 SINGLE PROTEIN Q9Z2V5

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832944 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005874 (microtubule)
GO:0005875 (microtubule associated complex)
GO:0005881 (cytoplasmic microtubule)
GO:0005901 (caveola)
GO:0016234 (inclusion body)
GO:0016235 (aggresome)
GO:0030286 (dynein complex)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031252 (cell leading edge)
GO:0032991 (macromolecular complex)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0044297 (cell body)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0003779 (actin binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008017 (microtubule binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019213 (deacetylase activity)
GO:0031593 (polyubiquitin binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0042826 (histone deacetylase binding)
GO:0042903 (tubulin deacetylase activity)
GO:0043014 (alpha-tubulin binding)
GO:0043130 (ubiquitin binding)
GO:0046872 (metal ion binding)
GO:0048156 (tau protein binding)
GO:0048487 (beta-tubulin binding)
GO:0051787 (misfolded protein binding)
GO:0051879 (Hsp90 protein binding)
GO:0070840 (dynein complex binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
GO:0006886 (intracellular protein transport)
GO:0007026 (negative regulation of microtubule depolymerization)
GO:0009636 (response to toxic substance)
GO:0009967 (positive regulation of signal transduction)
GO:0010033 (response to organic substance)
GO:0010469 (regulation of receptor activity)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0016241 (regulation of macroautophagy)
GO:0016575 (histone deacetylation)
GO:0031647 (regulation of protein stability)
GO:0032418 (lysosome localization)
GO:0032461 (positive regulation of protein oligomerization)
GO:0032984 (protein-containing complex disassembly)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0035967 (cellular response to topologically incorrect protein)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0043162 (ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)
GO:0043242 (negative regulation of protein complex disassembly)
GO:0045598 (regulation of fat cell differentiation)
GO:0045861 (negative regulation of proteolysis)
GO:0048668 (collateral sprouting)
GO:0051646 (mitochondrion localization)
GO:0051788 (response to misfolded protein)
GO:0060997 (dendritic spine morphogenesis)
GO:0061734 (parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)
GO:0070201 (regulation of establishment of protein localization)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070842 (aggresome assembly)
GO:0070845 (polyubiquitinated misfolded protein transport)
GO:0070846 (Hsp90 deacetylation)
GO:0070848 (response to growth factor)
GO:0070932 (histone H3 deacetylation)
GO:0071218 (cellular response to misfolded protein)
GO:0090035 (positive regulation of chaperone-mediated protein complex assembly)
GO:0090042 (tubulin deacetylation)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:1901300 (positive regulation of hydrogen peroxide-mediated programmed cell death)

Target Cross References - Protein

IntAct Q9Z2V5
Reactome R-MMU-3371511 (HSF1 activation.)
R-MMU-5617833 (Cilium Assembly.)
UniProt B1AUA6 Q9Z2V5

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR001607 (Znf_UBP.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)
PF02148 (zf-UBP)