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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2871
Preferred Name Cholecystokinin A receptor
Synonyms CCK-A receptor | CCK-AR | CCK1-R | Cckar | Cholecystokinin receptor type A | Cholecystokinin-1 receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > cholecystokinin receptor

Target Components

Component Description Relationship Accession
Cholecystokinin receptor type A SINGLE PROTEIN P30551

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096986 Cholecystokinin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043195 (terminal bouton)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004951 (cholecystokinin receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001696 (gastric acid secretion)
GO:0002023 (reduction of food intake in response to dietary excess)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007584 (response to nutrient)
GO:0007631 (feeding behavior)
GO:0009314 (response to radiation)
GO:0009408 (response to heat)
GO:0030073 (insulin secretion)
GO:0030157 (pancreatic juice secretion)
GO:0031016 (pancreas development)
GO:0031100 (organ regeneration)
GO:0031532 (actin cytoskeleton reorganization)
GO:0032496 (response to lipopolysaccharide)
GO:0032870 (cellular response to hormone stimulus)
GO:0038188 (cholecystokinin signaling pathway)
GO:0042594 (response to starvation)
GO:0042755 (eating behavior)
GO:0043266 (regulation of potassium ion transport)
GO:0046883 (regulation of hormone secretion)
GO:0048545 (response to steroid hormone)
GO:0051384 (response to glucocorticoid)
GO:0051924 (regulation of calcium ion transport)
GO:0090274 (positive regulation of somatostatin secretion)
GO:1901652 (response to peptide)

Target Cross References - Protein

canSAR P30551
Guide to Pharmacology 76
UniProt P30551

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000596 (Cholcy_rcpt_A.)
IPR009126 (Cholcskin_rcpt.)
IPR015276 (CholecystokininA_recpt_N.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR036472 (CholecystokininA_recpt_N_sf.)
Pfam PF00001 (7tm_1)
PF09193 (CholecysA-Rec_N)