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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL286
Preferred Name Renin
Synonyms Angiotensinogenase | REN | Renin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a1a subfamily

Target Components

Component Description Relationship Accession

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545059 ALISKIREN FUMARATE Renin inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143839
Ensembl ENSG00000143839
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004190 (aspartic-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005159 (insulin-like growth factor receptor binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001822 (kidney development)
GO:0001823 (mesonephros development)
GO:0002003 (angiotensin maturation)
GO:0002016 (regulation of blood volume by renin-angiotensin)
GO:0002018 (renin-angiotensin regulation of aldosterone production)
GO:0006508 (proteolysis)
GO:0008217 (regulation of blood pressure)
GO:0008584 (male gonad development)
GO:0009755 (hormone-mediated signaling pathway)
GO:0010033 (response to organic substance)
GO:0030163 (protein catabolic process)
GO:0032496 (response to lipopolysaccharide)
GO:0035690 (cellular response to drug)
GO:0035902 (response to immobilization stress)
GO:0042493 (response to drug)
GO:0042756 (drinking behavior)
GO:0043408 (regulation of MAPK cascade)
GO:0048469 (cell maturation)
GO:0050435 (beta-amyloid metabolic process)
GO:0051591 (response to cAMP)
GO:0070305 (response to cGMP)
Wikipedia Renin

Target Cross References - Protein

canSAR P00797
CGD Hyperuricemic nephropathy, familial juvenile 2
Human Protein Atlas ENSG00000143839
IntAct P00797
Guide to Pharmacology 2413
Open Targets ENSG00000143839
PharmGKB PA297
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt P00797 Q6FI38 Q6T5C2

Target Cross References - Domain

InterPro IPR001461 (Aspartic_peptidase_A1.)
IPR001969 (Aspartic_peptidase_AS.)
IPR012848 (Aspartic_peptidase_N.)
IPR021109 (Peptidase_aspartic_dom_sf.)
IPR034135 (Renin-like_dom.)
Pfam PF00026 (Asp)
PF07966 (A1_Propeptide)

Target Cross References - Structure

PDBe 1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN More...
CREDO 1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN More...