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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2858
Target Type SINGLE PROTEIN
Preferred Name Mu opioid receptor
Synonyms M-OR-1 | MOR-1 | Mor | Mu-type opioid receptor | Oprm | Oprm1
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Mu-type opioid receptor SINGLE PROTEIN P42866

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221343 Opioid receptors; mu and delta PROTEIN FAMILY
CHEMBL2095192 Opioid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032590 (dendrite membrane)
GO:0032839 (dendrite cytoplasm)
GO:0042383 (sarcolemma)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0045121 (membrane raft)
GO:0098794 (postsynapse)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004979 (beta-endorphin receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0019904 (protein domain specific binding)
GO:0031005 (filamin binding)
GO:0031681 (G-protein beta-subunit binding)
GO:0038047 (morphine receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0002438 (acute inflammatory response to antigenic stimulus)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007626 (locomotory behavior)
GO:0009314 (response to radiation)
GO:0019233 (sensory perception of pain)
GO:0031635 (adenylate cyclase-inhibiting opioid receptor signaling pathway)
GO:0032094 (response to food)
GO:0032100 (positive regulation of appetite)
GO:0032496 (response to lipopolysaccharide)
GO:0038003 (opioid receptor signaling pathway)
GO:0042060 (wound healing)
GO:0042220 (response to cocaine)
GO:0042755 (eating behavior)
GO:0043278 (response to morphine)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0044849 (estrous cycle)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045471 (response to ethanol)
GO:0048149 (behavioral response to ethanol)
GO:0050769 (positive regulation of neurogenesis)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0061358 (negative regulation of Wnt protein secretion)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0070848 (response to growth factor)
GO:0071315 (cellular response to morphine)
GO:0080135 (regulation of cellular response to stress)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)

Target Cross References - Protein

canSAR P42866
IntAct P42866
Guide to Pharmacology 319
MICAD NBK23273 (Mu opioid receptor)
Reactome R-MMU-111885 (Opioid Signalling.)
R-MMU-202040 (G-protein activation.)
R-MMU-375276 (Peptide ligand-binding receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt A1XGX3 A1XGX4 A1YAC3 A1YAC4 A5H7G2 P42866 Q4U2P4 Q4U2Q6 Q548C6 Q60768 Q6YC50 Q8CAN5 Q8CGW2 Q8CH73 Q8CH74 Q8CH75 Q8VBU3 Q8VBU6 Q8VBX8 Q8VI69 Q8VI70 Q8VI71 Q8VIN3 Q8VIN4 Q8VIN5 Q8VIN6 Q8VIP0 Q8VIP1 Q9JIY1 Q9R0D1 Q9R1L9 Q9R1M0

Target Cross References - Domain

InterPro IPR000105 (Mu_opioid_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4DKL 5C1M
CREDO 4DKL 5C1M
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