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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2820
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor XI
Synonyms Coagulation factor XI | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FXI | PTA | Plasma thromboplastin antecedent
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Coagulation factor XI SINGLE PROTEIN P03951

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000088926
Ensembl ENSG00000088926
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042802 (identical protein binding)
GO:0070009 (serine-type aminopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007596 (blood coagulation)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0007599 (hemostasis)
GO:0030193 (regulation of blood coagulation)
GO:0031639 (plasminogen activation)
GO:0051919 (positive regulation of fibrinolysis)
Wikipedia Factor_XI

Target Cross References - Protein

canSAR P03951
CGD Factor XI deficiency
Human Protein Atlas ENSG00000088926
IntAct P03951
Guide to Pharmacology 2360
Open Targets ENSG00000088926
PharmGKB PA27941
Reactome R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
UniProt D3DP64 P03951 Q4W5C2 Q9Y495

Target Cross References - Domain

InterPro IPR000177 (Apple.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR003609 (Pan_app.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
IPR035696 (Coagulation_factor_XI.)
Pfam PF00024 (PAN_1)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA More...
CREDO 1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA More...
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