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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL281
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase IV
Synonyms CA-IV | CA4 | Carbonate dehydratase IV | Carbonic anhydrase 4 | Carbonic anhydrase IV
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Carbonic anhydrase 4 SINGLE PROTEIN Q95323

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096971 Carbonic anhydrase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005791 (rough endoplasmic reticulum)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005794 (Golgi apparatus)
GO:0005802 (trans-Golgi network)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0030658 (transport vesicle membrane)
GO:0030667 (secretory granule membrane)
GO:0031225 (anchored component of membrane)
GO:0031362 (anchored component of external side of plasma membrane)
GO:0031526 (brush border membrane)
GO:0046658 (anchored component of plasma membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0015701 (bicarbonate transport)

Target Cross References - Protein

canSAR Q95323
Reactome R-BTA-1237044 (Erythrocytes take up carbon dioxide and release oxygen.)
R-BTA-1247673 (Erythrocytes take up oxygen and release carbon dioxide.)
R-BTA-1475029 (Reversible hydration of carbon dioxide.)
UniProt A5PKL8 Q95323

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018343 (Carbonic_anhydrase_CA4.)
IPR023561 (Carbonic_anhydrase_a-class.)
IPR036398 (Carbonic_anhydrase_a_sf.)
Pfam PF00194 (Carb_anhydrase)
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