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Target Report Card

Target Name and Classification

Target ID CHEMBL2789
Preferred Name Estradiol 17-beta-dehydrogenase 2
Synonyms 17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | E2DH | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenase | SDR9C2 | Short chain dehydrogenase/reductase family 9C member 2 | Testosterone 17-beta-dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Estradiol 17-beta-dehydrogenase 2 SINGLE PROTEIN P37059

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000086696
Ensembl ENSG00000086696
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004303 (estradiol 17-beta-dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO:0047006 (17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity)
GO:0047035 (testosterone dehydrogenase (NAD+) activity)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0001890 (placenta development)
GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0032526 (response to retinoic acid)
GO:0055114 (oxidation-reduction process)
Wikipedia HSD17B2

Target Cross References - Protein

canSAR P37059
Human Protein Atlas ENSG00000086696
IntAct P37059
Open Targets ENSG00000086696
PharmGKB PA29479
Reactome R-HSA-193144 (Estrogen biosynthesis.)
UniProt B2R7T4 P37059

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR016040 (NAD(P)-bd_dom.)
IPR020904 (Sc_DH/Rdtase_CS.)
Pfam PF00106 (adh_short)