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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2758
Target Type SINGLE PROTEIN
Preferred Name Mannose-6-phosphate isomerase
Synonyms MPI | Mannose-6-phosphate isomerase | PMI | PMI1 | Phosphohexomutase | Phosphomannose isomerase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > isomerase

Target Components

Component Description Relationship Accession
Mannose-6-phosphate isomerase SINGLE PROTEIN P34949

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178802
Ensembl ENSG00000178802
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004476 (mannose-6-phosphate isomerase activity)
GO:0008270 (zinc ion binding)
GO:0016853 (isomerase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000032 (cell wall mannoprotein biosynthetic process)
GO:0005975 (carbohydrate metabolic process)
GO:0006486 (protein glycosylation)
GO:0009298 (GDP-mannose biosynthetic process)
GO:0061611 (mannose to fructose-6-phosphate metabolic process)

Target Cross References - Protein

canSAR P34949
CGD Congenital disorder of glycosylation, type Ib
Human Protein Atlas ENSG00000178802
IntAct P34949
Open Targets ENSG00000178802
PharmGKB PA30922
Reactome R-HSA-4043916 (Defective MPI causes MPI-CDG (CDG-1b).)
R-HSA-446205 (Synthesis of GDP-mannose.)
UniProt A8K8K9 P34949 Q96AB0

Target Cross References - Domain

InterPro IPR001250 (Man6P_Isoase-1.)
IPR011051 (RmlC_Cupin_sf.)
IPR014710 (RmlC-like_jellyroll.)
IPR016305 (Mannose-6-P_Isomerase.)
IPR018050 (Pmannose_isomerase-type1_CS.)
Pfam PF01238 (PMI_typeI)
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