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Target Report Card

Target Name and Classification

Target ID CHEMBL274
Preferred Name C-C chemokine receptor type 5
Synonyms C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5 | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 5 SINGLE PROTEIN P51681

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301384 CCR5/mu opioid receptor complex PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201187 MARAVIROC C-C chemokine receptor type 5 antagonist 4 DailyMed
CHEMBL1668019 APLAVIROC HYDROCHLORIDE C-C chemokine receptor type 5 antagonist 3 PubMed PubMed
CHEMBL2107384 VICRIVIROC MALEATE C-C chemokine receptor type 5 antagonist 3 PubMed
CHEMBL2110727 CENICRIVIROC C-C chemokine receptor type 5 antagonist 3 PubMed PubMed PubMed
CHEMBL1688243 INCB-9471 C-C chemokine receptor type 5 antagonist 2 PubMed PubMed
CHEMBL1951914 AZD5672 C-C chemokine receptor type 5 antagonist 2 PubMed PubMed
CHEMBL2109343 PRO-140 C-C chemokine receptor type 5 antagonist 2 PubMed
CHEMBL3545032 PF-04634817 C-C chemokine receptor type 5 antagonist 2 Other
CHEMBL2109341 CCR5MAB004 C-C chemokine receptor type 5 inhibitor 1 PubMed
CHEMBL2109342 HGS-1025 C-C chemokine receptor type 5 inhibitor 1 ClinicalTrials Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160791
Ensembl ENSG00000160791
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0003779 (actin binding)
GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0005515 (protein binding)
GO:0015026 (coreceptor activity)
GO:0016493 (C-C chemokine receptor activity)
GO:0019957 (C-C chemokine binding)
GO:0071791 (chemokine (C-C motif) ligand 5 binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0002407 (dendritic cell chemotaxis)
GO:0006816 (calcium ion transport)
GO:0006935 (chemotaxis)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0014808 (release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0016032 (viral process)
GO:0019064 (fusion of virus membrane with host plasma membrane)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019722 (calcium-mediated signaling)
GO:0023052 (signaling)
GO:0030260 (entry into host cell)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0070723 (response to cholesterol)
GO:0071222 (cellular response to lipopolysaccharide)
GO:2000110 (negative regulation of macrophage apoptotic process)
Wikipedia CCR5

Target Cross References - Protein

canSAR P51681
Human Protein Atlas ENSG00000160791
IntAct P51681
Guide to Pharmacology 62
Open Targets ENSG00000160791
PharmGKB PA26170
Pharos P51681 (Tclin)
Reactome R-HSA-173107 (Binding and entry of HIV virion.)
R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6783783 (Interleukin-10 signaling.)
UniProt O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702 O14703 O14704 O14705 O14706 O14707 O14708 O15538 P51681 Q9UPA4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR002240 (Chemokine_CCR5.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure