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Target Report Card

Target Name and Classification

Target ID CHEMBL2734
Preferred Name Phospholipase D2
Synonyms Choline phosphatase 2 | PLD 2 | PLD1C | PLD2 | Phosphatidylcholine-hydrolyzing phospholipase D2 | Phospholipase D2 | hPLD2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Phospholipase D2 SINGLE PROTEIN O14939

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129219
Ensembl ENSG00000129219
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0098793 (presynapse)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004630 (phospholipase D activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0035091 (phosphatidylinositol binding)
GO:0070290 (N-acylphosphatidylethanolamine-specific phospholipase D activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0007010 (cytoskeleton organization)
GO:0007264 (small GTPase mediated signal transduction)
GO:0016042 (lipid catabolic process)
GO:0036465 (synaptic vesicle recycling)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0048017 (inositol lipid-mediated signaling)
GO:0048870 (cell motility)
Wikipedia PLD2

Target Cross References - Protein

canSAR O14939
Human Protein Atlas ENSG00000129219
IntAct O14939
Guide to Pharmacology 1434
Open Targets ENSG00000129219
PharmGKB PA33397
Reactome R-HSA-1483148 (Synthesis of PG.)
R-HSA-1483166 (Synthesis of PA.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
UniProt I3L2C9 O14939 O43540 O43579 O43580 Q6PGR0 Q96BY3

Target Cross References - Domain

InterPro IPR001683 (Phox.)
IPR001736 (PLipase_D/transphosphatidylase.)
IPR001849 (PH_domain.)
IPR011993 (PH-like_dom_sf.)
IPR015679 (PLipase_D_fam.)
IPR016555 (PLipase_D_euk.)
IPR025202 (PLD-like_dom.)
IPR036871 (PX_dom_sf.)
Pfam PF00614 (PLDc)
PF00787 (PX)
PF13091 (PLDc_2)