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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL270
Target Type SINGLE PROTEIN
Preferred Name Mu opioid receptor
Synonyms M-OR-1 | MOR-1 | Mu-type opioid receptor | Opioid receptor B | Oprm1 | Ror-b
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Mu-type opioid receptor SINGLE PROTEIN P33535

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095155 Opioid receptors; mu & delta SELECTIVITY GROUP
CHEMBL2094129 Opioid receptor PROTEIN FAMILY
CHEMBL3038507 Nociceptin/mu opioid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032590 (dendrite membrane)
GO:0032839 (dendrite cytoplasm)
GO:0042383 (sarcolemma)
GO:0042995 (cell projection)
GO:0043204 (perikaryon)
GO:0045121 (membrane raft)
GO:0098794 (postsynapse)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004979 (beta-endorphin receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0019904 (protein domain specific binding)
GO:0031005 (filamin binding)
GO:0031681 (G-protein beta-subunit binding)
GO:0038047 (morphine receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0002438 (acute inflammatory response to antigenic stimulus)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007626 (locomotory behavior)
GO:0009314 (response to radiation)
GO:0019233 (sensory perception of pain)
GO:0031635 (adenylate cyclase-inhibiting opioid receptor signaling pathway)
GO:0032094 (response to food)
GO:0032100 (positive regulation of appetite)
GO:0032496 (response to lipopolysaccharide)
GO:0038003 (opioid receptor signaling pathway)
GO:0042060 (wound healing)
GO:0042220 (response to cocaine)
GO:0042755 (eating behavior)
GO:0043278 (response to morphine)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0044849 (estrous cycle)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0045471 (response to ethanol)
GO:0048149 (behavioral response to ethanol)
GO:0050769 (positive regulation of neurogenesis)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0061358 (negative regulation of Wnt protein secretion)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0070848 (response to growth factor)
GO:0071315 (cellular response to morphine)
GO:0080135 (regulation of cellular response to stress)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)

Target Cross References - Protein

canSAR P33535
IntAct P33535
Guide to Pharmacology 319
MICAD NBK23273 (Mu opioid receptor)
Reactome R-RNO-111885 (Opioid Signalling.)
R-RNO-202040 (G-protein activation.)
R-RNO-375276 (Peptide ligand-binding receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P33535 Q2TV20 Q2TV21 Q4VWM5 Q4VWM7 Q4VWX7 Q4VWX8 Q62846 Q64064 Q64120

Target Cross References - Domain

InterPro IPR000105 (Mu_opioid_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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