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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL268
Preferred Name Cathepsin K
Synonyms CTSK | CTSO | CTSO2 | Cathepsin K | Cathepsin O | Cathepsin O2 | Cathepsin X
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin K SINGLE PROTEIN P43235

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111368 Cathepsin (S and K) SELECTIVITY GROUP
CHEMBL2111396 Cathepsin (B and K) SELECTIVITY GROUP
CHEMBL2111361 Cathepsin (V and K) SELECTIVITY GROUP
CHEMBL2111380 Cathepsin (L and K) SELECTIVITY GROUP
CHEMBL2111441 Cathepsin (H and K) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL481611 ODANACATIB Cathepsin K inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143387
Ensembl ENSG00000143387
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0036021 (endolysosome lumen)
GO:0043202 (lysosomal lumen)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0043394 (proteoglycan binding)
GO Biological Process GO:0000422 (mitophagy)
GO:0001957 (intramembranous ossification)
GO:0002224 (toll-like receptor signaling pathway)
GO:0006508 (proteolysis)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0045453 (bone resorption)
GO:0045616 (regulation of keratinocyte differentiation)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
Wikipedia Cathepsin_K

Target Cross References - Protein

canSAR P43235
CGD Pycnodysostosis
Human Protein Atlas ENSG00000143387
IntAct P43235
Guide to Pharmacology 2350
Open Targets ENSG00000143387
PharmGKB PA27034
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-8939242 (RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.)
UniProt P43235 Q6FHS6

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR013201 (Prot_inhib_I29.)
IPR015644 (Peptidase_C1A_cathepsin-K.)
IPR025660 (Pept_his_AS.)
IPR025661 (Pept_asp_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO More...
CREDO 1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO More...