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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2664
Target Type SINGLE PROTEIN
Preferred Name Adenosylhomocysteinase
Synonyms AHCY | Adenosylhomocysteinase | AdoHcyase | S-adenosyl-L-homocysteine hydrolase | SAHH
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenosylhomocysteinase SINGLE PROTEIN P23526

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101444
Ensembl ENSG00000101444
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0042470 (melanosome)
GO:0043005 (neuron projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004013 (adenosylhomocysteinase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0030554 (adenyl nucleotide binding)
GO:0042802 (identical protein binding)
GO:0051287 (NAD binding)
GO Biological Process GO:0000096 (sulfur amino acid metabolic process)
GO:0001666 (response to hypoxia)
GO:0002439 (chronic inflammatory response to antigenic stimulus)
GO:0006730 (one-carbon metabolic process)
GO:0007584 (response to nutrient)
GO:0019510 (S-adenosylhomocysteine catabolic process)
GO:0032259 (methylation)
GO:0033353 (S-adenosylmethionine cycle)
GO:0042745 (circadian sleep/wake cycle)
GO:0071268 (homocysteine biosynthetic process)

Target Cross References - Protein

canSAR P23526
CGD Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency
Human Protein Atlas ENSG00000101444
IntAct P23526
Guide to Pharmacology 1233
Open Targets ENSG00000101444
PharmGKB PA24636
Reactome R-HSA-156581 (Methylation.)
R-HSA-1614635 (Sulfur amino acid metabolism.)
R-HSA-2408508 (Metabolism of ingested SeMet, Sec, MeSec into H2Se.)
R-HSA-5578997 (Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD).)
UniProt A8K307 B3KUN3 E1P5P2 F5H737 P23526 Q96A36

Target Cross References - Domain

InterPro IPR000043 (Adenosylhomocysteinase-like.)
IPR015878 (Ado_hCys_hydrolase_NAD-bd.)
IPR020082 (S-Ado-L-homoCys_hydrolase_CS.)
IPR034373 (Adenosylhomocysteinase.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00670 (AdoHcyase_NAD)
PF05221 (AdoHcyase)

Target Cross References - Structure

PDBe 1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B
CREDO 1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B
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