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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2635
Target Type SINGLE PROTEIN
Preferred Name Dual specificity protein phosphatase 3
Synonyms DUSP3 | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | VHR | VHR | Vaccinia H1-related phosphatase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine/tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Dual specificity protein phosphatase 3 SINGLE PROTEIN P51452

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108861
Ensembl ENSG00000108861
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0008138 (protein tyrosine/serine/threonine phosphatase activity)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019901 (protein kinase binding)
GO:0033549 (MAP kinase phosphatase activity)
GO Biological Process GO:0000188 (inactivation of MAPK activity)
GO:0001701 (in utero embryonic development)
GO:0006470 (protein dephosphorylation)
GO:0016311 (dephosphorylation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0043409 (negative regulation of MAPK cascade)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046329 (negative regulation of JNK cascade)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0050868 (negative regulation of T cell activation)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
Wikipedia DUSP3

Target Cross References - Protein

canSAR P51452
Human Protein Atlas ENSG00000108861
IntAct P51452
Open Targets ENSG00000108861
PharmGKB PA27526
Reactome R-HSA-202670 (ERKs are inactivated.)
UniProt D3DX45 P51452 Q5U0J1 Q8IYJ9

Target Cross References - Domain

InterPro IPR000340 (Dual-sp_phosphatase_cat-dom.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR016130 (Tyr_Pase_AS.)
IPR020405 (Atypical_DUSP_famA.)
IPR020417 (Atypical_DUSP.)
IPR020422 (TYR_PHOSPHATASE_DUAL_dom.)
IPR024950 (DUSP.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00782 (DSPc)

Target Cross References - Structure

PDBe 1J4X 1VHR 3F81
CREDO 1J4X 1VHR 3F81
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