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Target Report Card

Target Name and Classification

Target ID CHEMBL2625
Preferred Name Angiotensin-converting enzyme
Synonyms ACE | Ace | Angiotensin-converting enzyme | Angiotensin-converting enzyme, soluble form | CD_antigen=CD143 | Dcp1 | Dipeptidyl carboxypeptidase I | Kininase II
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m2 family

Target Components

Component Description Relationship Accession
Angiotensin-converting enzyme SINGLE PROTEIN P47820

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009925 (basal plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031526 (brush border membrane)
GO:0031982 (vesicle)
GO:0097225 (sperm midpiece)
GO Molecular Function GO:0004180 (carboxypeptidase activity)
GO:0008144 (drug binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008241 (peptidyl-dipeptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001822 (kidney development)
GO:0003084 (positive regulation of systemic arterial blood pressure)
GO:0006508 (proteolysis)
GO:0006518 (peptide metabolic process)
GO:0007420 (brain development)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008217 (regulation of blood pressure)
GO:0008584 (male gonad development)
GO:0009792 (embryo development ending in birth or egg hatching)
GO:0010815 (bradykinin catabolic process)
GO:0014910 (regulation of smooth muscle cell migration)
GO:0019233 (sensory perception of pain)
GO:0030324 (lung development)
GO:0031100 (organ regeneration)
GO:0031667 (response to nutrient levels)
GO:0032496 (response to lipopolysaccharide)
GO:0034616 (response to laminar fluid shear stress)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0042310 (vasoconstriction)
GO:0042493 (response to drug)
GO:0042755 (eating behavior)
GO:0043065 (positive regulation of apoptotic process)
GO:0043171 (peptide catabolic process)
GO:0045777 (positive regulation of blood pressure)
GO:0046325 (negative regulation of glucose import)
GO:0048286 (lung alveolus development)
GO:0050729 (positive regulation of inflammatory response)
GO:0050769 (positive regulation of neurogenesis)
GO:0060978 (angiogenesis involved in coronary vascular morphogenesis)
GO:0071333 (cellular response to glucose stimulus)
GO:0071548 (response to dexamethasone)
GO:0090281 (negative regulation of calcium ion import)
GO:0097066 (response to thyroid hormone)
GO:0097756 (negative regulation of blood vessel diameter)
GO:1904045 (cellular response to aldosterone)

Target Cross References - Protein

canSAR P47820
Guide to Pharmacology 1613
UniProt P47820 Q7TMC6 Q8CFN1 Q9EQM9

Target Cross References - Domain

InterPro IPR001548 (Peptidase_M2.)
Pfam PF01401 (Peptidase_M2)