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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2568
Target Type SINGLE PROTEIN
Preferred Name Liver glycogen phosphorylase
Synonyms Glycogen phosphorylase, liver form | PYGL
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glycogen phosphorylase, liver form SINGLE PROTEIN P06737

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100504
Ensembl ENSG00000100504
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0034774 (secretory granule lumen)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002060 (purine nucleobase binding)
GO:0003824 (catalytic activity)
GO:0004645 (phosphorylase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005536 (glucose binding)
GO:0008144 (drug binding)
GO:0008184 (glycogen phosphorylase activity)
GO:0016208 (AMP binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0019842 (vitamin binding)
GO:0030170 (pyridoxal phosphate binding)
GO:0030246 (carbohydrate binding)
GO:0032052 (bile acid binding)
GO:0042803 (protein homodimerization activity)
GO:0102250 (linear malto-oligosaccharide phosphorylase activity)
GO:0102499 (SHG alpha-glucan phosphorylase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005980 (glycogen catabolic process)
GO:0006015 (5-phosphoribose 1-diphosphate biosynthetic process)
GO:0008152 (metabolic process)
GO:0042593 (glucose homeostasis)
GO:0043312 (neutrophil degranulation)
GO:0070266 (necroptotic process)

Target Cross References - Protein

canSAR P06737
CGD Glycogen storage disease VI
Human Protein Atlas ENSG00000100504
IntAct P06737
Open Targets ENSG00000100504
PharmGKB PA34068
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-70221 (Glycogen breakdown (glycogenolysis).)
UniProt A6NDQ4 B4DUB7 F5H816 O60567 O60752 O60913 P06737 Q501V9 Q641R5 Q96G82

Target Cross References - Domain

InterPro IPR000811 (Glyco_trans_35.)
IPR011833 (Glycg_phsphrylas.)
IPR035090 (Pyridoxal_P_attach_site.)
Pfam PF00343 (Phosphorylase)

Target Cross References - Structure

PDBe 1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW
CREDO 1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW
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