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Target Report Card

Target Name and Classification

Target ID CHEMBL2564
Preferred Name Metabotropic glutamate receptor 5
Synonyms Gprc1e | Grm5 | Metabotropic glutamate receptor 5 | Mglur5 | mGluR5
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > metabotropic glutamate receptor

Target Components

Component Description Relationship Accession
Metabotropic glutamate receptor 5 SINGLE PROTEIN P31424

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111335 Metabotropic glutamate receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042734 (presynaptic membrane)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0045211 (postsynaptic membrane)
GO:0097449 (astrocyte projection)
GO:0098839 (postsynaptic density membrane)
GO Molecular Function GO:0001639 (PLC activating G-protein coupled glutamate receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0008066 (glutamate receptor activity)
GO:0030165 (PDZ domain binding)
GO:0031687 (A2A adenosine receptor binding)
GO:1990782 (protein tyrosine kinase binding)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007196 (adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007206 (phospholipase C-activating G-protein coupled glutamate receptor signaling pathway)
GO:0007216 (G-protein coupled glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0040013 (negative regulation of locomotion)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048170 (positive regulation of long-term neuronal synaptic plasticity)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0099553 (trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)

Target Cross References - Protein

canSAR P31424
IntAct P31424
Guide to Pharmacology 293
MICAD NBK23136 (Metabotropic glutamate subtype 5 (mGlu5) receptor)
NBK23202 (Metabotropic glutamate subtype 5 (mGlu5) receptor)
NBK23358 (Metabotropic glutamate subtype 5 (mGlu5) receptor (mGluR5 or mGluR5))
NBK23553 (Metabotropic glutamate subtype 5 (mGlu5) receptor (mGluR5 or mGluR5))
NBK23648 (Metabotropic glutamate receptor subtype 5 (mGluR5))
NBK23672 (Metabotropic glutamate subtype 5 (mGlu5) receptor (mGluR5 or mGluR5))
NBK23687 (Metabotropic glutamate receptor subtype 5 (mGlu5))
NBK63866 (Metabotropic glutamate receptor subtype 5 (mGluR5))
UniProt P31424

Target Cross References - Domain

InterPro IPR000162 (GPCR_3_mtglu_rcpt.)
IPR000202 (GPCR_3_mtglu_rcpt_5.)
IPR000337 (GPCR_3.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
IPR019588 (Metabotropic_Glu_rcpt_Homer-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)
PF10606 (GluR_Homer-bdg)

Target Cross References - Structure