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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL256
Preferred Name Adenosine A3 receptor
Synonyms ADORA3 | Adenosine receptor A3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A3 SINGLE PROTEIN P0DMS8

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111329 Adenosine receptor PROTEIN FAMILY
CHEMBL2095213 Adenosine receptors; A2a & A3 SELECTIVITY GROUP
CHEMBL2095234 Adenosine receptors; A2b & A3 SELECTIVITY GROUP
CHEMBL2095195 Adenosine receptors; A1 & A3 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3989873 PICLIDENOSON Adenosine A3 receptor agonist 3 PubMed
CHEMBL431733 NAMODENOSON Adenosine A3 receptor agonist 2 PubMed
CHEMBL3545204 QAF805 Adenosine A3 receptor antagonist 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000282608
Ensembl ENSG00000282608
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0001973 (adenosine receptor signaling pathway)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0008016 (regulation of heart contraction)
GO:0008285 (negative regulation of cell proliferation)
GO:0009611 (response to wounding)
GO:0030336 (negative regulation of cell migration)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
Wikipedia Adenosine_A3_receptor

Target Cross References - Protein

canSAR P33765
Human Protein Atlas ENSG00000282608
Guide to Pharmacology 21
Open Targets ENSG00000282608
PharmGKB PA24589
Pharos P0DMS8 (Tchem)
Reactome R-HSA-417973 (Adenosine P1 receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A2A3P4 P0DMS8 P33765 Q6UWU0 Q9BYZ1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000466 (Adeno_A3_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)