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Target Report Card

Target Name and Classification

Target ID CHEMBL2536
Target Type SINGLE PROTEIN
Preferred Name Phospholipase D1
Synonyms Choline phosphatase 1 | PLD 1 | PLD1 | Phosphatidylcholine-hydrolyzing phospholipase D1 | Phospholipase D1 | hPLD1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Phospholipase D1 SINGLE PROTEIN Q13393

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075651
Ensembl ENSG00000075651
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0031902 (late endosome membrane)
GO:0035579 (specific granule membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070821 (tertiary granule membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004630 (phospholipase D activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0035091 (phosphatidylinositol binding)
GO:0070290 (N-acylphosphatidylethanolamine-specific phospholipase D activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0006935 (chemotaxis)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0016042 (lipid catabolic process)
GO:0032534 (regulation of microvillus assembly)
GO:0043312 (neutrophil degranulation)
GO:0048017 (inositol lipid-mediated signaling)
GO:0048870 (cell motility)
Wikipedia Phospholipase_D1

Target Cross References - Protein

canSAR Q13393
Human Protein Atlas ENSG00000075651
IntAct Q13393
Guide to Pharmacology 1433
Open Targets ENSG00000075651
PharmGKB PA164742228
Reactome R-HSA-1483148 (Synthesis of PG.)
R-HSA-1483166 (Synthesis of PA.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt Q13393

Target Cross References - Domain

InterPro IPR001683 (Phox.)
IPR001736 (PLipase_D/transphosphatidylase.)
IPR001849 (PH_domain.)
IPR011993 (PH-like_dom_sf.)
IPR015679 (PLipase_D_fam.)
IPR016555 (PLipase_D_euk.)
IPR025202 (PLD-like_dom.)
IPR036871 (PX_dom_sf.)
Pfam PF00169 (PH)
PF00614 (PLDc)
PF00787 (PX)
PF13091 (PLDc_2)
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