ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2524
Preferred Name Alpha-galactosidase A
Synonyms Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | GLA | INN=Agalsidase | Melibiase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alpha-galactosidase A SINGLE PROTEIN P06280

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL110458 MIGALASTAT Alpha-galactosidase A stabiliser 4 Other
CHEMBL2108214 AGALSIDASE ALFA Alpha-galactosidase A activator 4 Other PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102393
Ensembl ENSG00000102393
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO:0035578 (azurophil granule lumen)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004557 (alpha-galactosidase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0016936 (galactoside binding)
GO:0042803 (protein homodimerization activity)
GO:0052692 (raffinose alpha-galactosidase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0008152 (metabolic process)
GO:0009311 (oligosaccharide metabolic process)
GO:0016139 (glycoside catabolic process)
GO:0043312 (neutrophil degranulation)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0046477 (glycosylceramide catabolic process)
GO:0046479 (glycosphingolipid catabolic process)
GO:0051001 (negative regulation of nitric-oxide synthase activity)
Wikipedia Alpha-galactosidase

Target Cross References - Protein

canSAR P06280
CGD Fabry disease; Fabry disease, cardiac variant
Human Protein Atlas ENSG00000102393
IntAct P06280
Open Targets ENSG00000102393
PharmGKB PA28707
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P06280 Q6LER7

Target Cross References - Domain

InterPro IPR000111 (Glyco_hydro_27/36_CS.)
IPR002241 (Glyco_hydro_27.)
IPR013780 (Glyco_hydro_b.)
IPR013785 (Aldolase_TIM.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR035373 (Melibiase/NAGA_C.)
Pfam PF16499 (Melibiase_2)
PF17450 (Melibiase_2_C)

Target Cross References - Structure

PDBe 1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS
CREDO 1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS