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Target Report Card

Target Name and Classification

Target ID CHEMBL250
Target Type SINGLE PROTEIN
Preferred Name Platelet activating factor receptor
Synonyms PAF-R | PAFR | PAFr | PTAFR | Platelet-activating factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > paf receptor

Target Components

Component Description Relationship Accession
Platelet-activating factor receptor SINGLE PROTEIN P25105

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2110618 MINOPAFANT Platelet activating factor receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169403
Ensembl ENSG00000169403
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030667 (secretory granule membrane)
GO:0070821 (tertiary granule membrane)
GO Molecular Function GO:0001530 (lipopolysaccharide binding)
GO:0001875 (lipopolysaccharide receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004992 (platelet activating factor receptor activity)
GO:0005543 (phospholipid binding)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO:0051019 (mitogen-activated protein kinase binding)
GO Biological Process GO:0001816 (cytokine production)
GO:0002693 (positive regulation of cellular extravasation)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007567 (parturition)
GO:0009609 (response to symbiotic bacterium)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032496 (response to lipopolysaccharide)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032959 (inositol trisphosphate biosynthetic process)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
GO:0043312 (neutrophil degranulation)
GO:0043315 (positive regulation of neutrophil degranulation)
GO:0045056 (transcytosis)
GO:0045410 (positive regulation of interleukin-6 biosynthetic process)
GO:0045727 (positive regulation of translation)
GO:0045776 (negative regulation of blood pressure)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046683 (response to organophosphorus)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060732 (positive regulation of inositol phosphate biosynthetic process)
GO:0071258 (cellular response to gravity)
GO:0071320 (cellular response to cAMP)
GO:0071398 (cellular response to fatty acid)
GO:0071548 (response to dexamethasone)
GO:0097755 (positive regulation of blood vessel diameter)
GO:1902943 (positive regulation of voltage-gated chloride channel activity)
GO:1903039 (positive regulation of leukocyte cell-cell adhesion)
GO:1903238 (positive regulation of leukocyte tethering or rolling)
GO:1904058 (positive regulation of sensory perception of pain)
GO:1904300 (positive regulation of transcytosis)
GO:1904303 (positive regulation of maternal process involved in parturition)
GO:1904306 (positive regulation of gastro-intestinal system smooth muscle contraction)
GO:1904316 (response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine)
GO:1904317 (cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine)
Wikipedia Platelet-activating_factor_receptor

Target Cross References - Protein

canSAR P25105
Human Protein Atlas ENSG00000169403
IntAct P25105
Guide to Pharmacology 334
Open Targets ENSG00000169403
PharmGKB PA33933
Pharos P25105 (Tchem)
Reactome R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-877300 (Interferon gamma signaling.)
UniProt A3KMC8 A8K2H5 P25105

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002282 (PAF_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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