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Target Report Card

Target Name and Classification

Target ID CHEMBL2489
Preferred Name Prostanoid EP4 receptor
Synonyms PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin E2 receptor EP4 subtype SINGLE PROTEIN P32240

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO:0043025 (neuronal cell body)
GO:0044306 (neuron projection terminus)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004955 (prostaglandin receptor activity)
GO:0004957 (prostaglandin E receptor activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0002792 (negative regulation of peptide secretion)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007254 (JNK cascade)
GO:0008284 (positive regulation of cell proliferation)
GO:0009612 (response to mechanical stimulus)
GO:0010628 (positive regulation of gene expression)
GO:0010727 (negative regulation of hydrogen peroxide metabolic process)
GO:0010840 (regulation of circadian sleep/wake cycle, wakefulness)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0030278 (regulation of ossification)
GO:0032496 (response to lipopolysaccharide)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0033624 (negative regulation of integrin activation)
GO:0035810 (positive regulation of urine volume)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0042093 (T-helper cell differentiation)
GO:0042322 (negative regulation of circadian sleep/wake cycle, REM sleep)
GO:0042466 (chemokinesis)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045778 (positive regulation of ossification)
GO:0045780 (positive regulation of bone resorption)
GO:0045785 (positive regulation of cell adhesion)
GO:0046010 (positive regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0050710 (negative regulation of cytokine secretion)
GO:0050712 (negative regulation of interleukin-1 alpha secretion)
GO:0050714 (positive regulation of protein secretion)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050728 (negative regulation of inflammatory response)
GO:0050729 (positive regulation of inflammatory response)
GO:0051492 (regulation of stress fiber assembly)
GO:0051771 (negative regulation of nitric-oxide synthase biosynthetic process)
GO:0060348 (bone development)
GO:0070257 (positive regulation of mucus secretion)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0090303 (positive regulation of wound healing)
GO:0097070 (ductus arteriosus closure)
GO:1900127 (positive regulation of hyaluronan biosynthetic process)
GO:1904336 (negative regulation of ductus arteriosus closure)
GO:1904348 (negative regulation of small intestine smooth muscle contraction)
GO:1904364 (positive regulation of calcitonin secretion)
GO:1904367 (positive regulation of chemokinesis)
GO:1904460 (positive regulation of substance P secretion)
GO:1904466 (positive regulation of matrix metallopeptidase secretion)
GO:1904468 (negative regulation of tumor necrosis factor secretion)
GO:1904471 (negative regulation of endothelin secretion)
GO:1904496 (positive regulation of substance P secretion, neurotransmission)
GO:2000386 (positive regulation of ovarian follicle development)
GO:2000388 (positive regulation of antral ovarian follicle growth)
GO:2000391 (positive regulation of neutrophil extravasation)
GO:2000420 (negative regulation of eosinophil extravasation)
GO:2001181 (positive regulation of interleukin-10 secretion)

Target Cross References - Protein

canSAR P32240
Guide to Pharmacology 343
Reactome R-MMU-391908 (Prostanoid ligand receptors.)
R-MMU-418555 (G alpha (s) signalling events.)
UniProt P32240

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001244 (Prostglndn_DP_rcpt.)
IPR001758 (Prost_EP4_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)