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Target Report Card

Target Name and Classification

Target ID CHEMBL248
Preferred Name Leukocyte elastase
Synonyms Bone marrow serine protease | ELA2 | ELANE | Elastase-2 | HLE | Human leukocyte elastase | Medullasin | Neutrophil elastase | PMN elastase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Neutrophil elastase SINGLE PROTEIN P08246

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197561 ENSG00000277571
Ensembl ENSG00000197561 ENSG00000277571
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO:0017053 (transcriptional repressor complex)
GO:0030141 (secretory granule)
GO:0035578 (azurophil granule lumen)
GO:0035580 (specific granule lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001106 (RNA polymerase II transcription corepressor activity)
GO:0002020 (protease binding)
GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0019955 (cytokine binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001878 (response to yeast)
GO:0002438 (acute inflammatory response to antigenic stimulus)
GO:0002523 (leukocyte migration involved in inflammatory response)
GO:0002812 (biosynthetic process of antibacterial peptides active against Gram-negative bacteria)
GO:0006508 (proteolysis)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006909 (phagocytosis)
GO:0009411 (response to UV)
GO:0019730 (antimicrobial humoral response)
GO:0022617 (extracellular matrix disassembly)
GO:0030163 (protein catabolic process)
GO:0032496 (response to lipopolysaccharide)
GO:0042742 (defense response to bacterium)
GO:0043312 (neutrophil degranulation)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0045079 (negative regulation of chemokine biosynthetic process)
GO:0045415 (negative regulation of interleukin-8 biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050728 (negative regulation of inflammatory response)
GO:0050778 (positive regulation of immune response)
GO:0050832 (defense response to fungus)
GO:0050900 (leukocyte migration)
GO:0050922 (negative regulation of chemotaxis)
GO:0070945 (neutrophil mediated killing of gram-negative bacterium)
GO:0070947 (neutrophil mediated killing of fungus)
GO:1903238 (positive regulation of leukocyte tethering or rolling)
Wikipedia Neutrophil_elastase

Target Cross References - Protein

canSAR P08246
CGD Neutropenia, severe congenital 1, autosomal dominant; Neutropenia, cyclic
Human Protein Atlas ENSG00000197561 ENSG00000277571
IntAct P08246
Guide to Pharmacology 2358
Open Targets ENSG00000197561 ENSG00000277571
PharmGKB PA27735
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6803157 (Antimicrobial peptides.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt P08246 P09649 Q6B0D9 Q6LDP5

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW
CREDO 1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW