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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL247
Target Type SINGLE PROTEIN
Preferred Name Human immunodeficiency virus type 1 reverse transcriptase
Synonyms Reverse transcriptase/RNaseH | pol
Organism Human immunodeficiency virus 1
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Reverse transcriptase/RNaseH SINGLE PROTEIN Q72547

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL57 NEVIRAPINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL129 ZIDOVUDINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL141 LAMIVUDINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL853 ZALCITABINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 FDA
CHEMBL885 EMTRICITABINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL929 DELAVIRDINE MESYLATE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL991 STAVUDINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 FDA
CHEMBL308954 ETRAVIRINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL223228 EFAVIRENZ Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL1460 DIDANOSINE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL1486 TENOFOVIR DISOPROXIL FUMARATE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL1200619 ABACAVIR SULFATE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL1628504 RILPIVIRINE HYDROCHLORIDE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
CHEMBL2107825 TENOFOVIR ALAFENAMIDE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 FDA
CHEMBL2364637 TENOFOVIR ALAFENAMIDE FUMARATE Human immunodeficiency virus type 1 reverse transcriptase inhibitor 4 DailyMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0003676 (nucleic acid binding)
GO:0003964 (RNA-directed DNA polymerase activity)
GO:0004523 (RNA-DNA hybrid ribonuclease activity)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006278 (RNA-dependent DNA biosynthetic process)
GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic)

Target Cross References - Protein

canSAR Q72547
IntAct Q72547
UniProt Q72547

Target Cross References - Domain

InterPro IPR000477 (RT_dom.)
IPR002156 (RNaseH_domain.)
IPR010659 (RVT_connect.)
IPR010661 (RVT_thumb.)
IPR012337 (RNaseH-like_sf.)
IPR036397 (RNaseH_sf.)
Pfam PF00075 (RNase_H)
PF00078 (RVT_1)
PF06815 (RVT_connect)
PF06817 (RVT_thumb)

Target Cross References - Structure

PDBe 2JLE 3HYF
CREDO 2JLE 3HYF
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