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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL243
Target Type SINGLE PROTEIN
Preferred Name Human immunodeficiency virus type 1 protease
Synonyms Pol polyprotein | pol
Organism Human immunodeficiency virus 1
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a2a subfamily

Target Components

Component Description Relationship Accession
Pol polyprotein SINGLE PROTEIN Q72874

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL114 SAQUINAVIR Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL116 AMPRENAVIR Human immunodeficiency virus type 1 protease inhibitor 4 FDA
CHEMBL282042 SAQUINAVIR MESYLATE Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL729 LOPINAVIR Human immunodeficiency virus type 1 protease inhibitor 4 FDA
CHEMBL163 RITONAVIR Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL1205 NELFINAVIR MESYLATE Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL222559 TIPRANAVIR Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL1735 INDINAVIR SULFATE Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL1200678 ATAZANAVIR SULFATE Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
CHEMBL1200734 FOSAMPRENAVIR CALCIUM Human immunodeficiency virus type 1 protease inhibitor 4 FDA
CHEMBL1201127 DARUNAVIR ETHANOLATE Human immunodeficiency virus type 1 protease inhibitor 4 DailyMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0004190 (aspartic-type endopeptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)

Target Cross References - Protein

canSAR Q72874
UniProt Q72874

Target Cross References - Domain

InterPro IPR001969 (Aspartic_peptidase_AS.)
IPR001995 (Peptidase_A2_cat.)
IPR018061 (Retropepsins.)
IPR021109 (Peptidase_aspartic_dom_sf.)
IPR034170 (Retropepsin-like_cat_dom.)
Pfam PF00077 (RVP)

Target Cross References - Structure

PDBe 5V4Y
CREDO 5V4Y
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