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Target Report Card

Target Name and Classification

Target ID CHEMBL2424504
Target Type SINGLE PROTEIN
Preferred Name Lysine-specific demethylase 5A
Synonyms Histone demethylase JARID1A | Jumonji/ARID domain-containing protein 1A | KDM5A | Lysine-specific demethylase 5A | RBBP-2 | RBBP2 | RBP2 | Retinoblastoma-binding protein 2 | Synonyms=JARID1A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > lysine demethylase > jumonji domain-containing
  • epigenetic regulator > reader > plant homeodomain

Target Components

Component Description Relationship Accession
Lysine-specific demethylase 5A SINGLE PROTEIN P29375

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073614
Ensembl ENSG00000073614
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0019907 (cyclin-dependent protein kinase activating kinase holoenzyme complex)
GO:0032993 (protein-DNA complex)
GO Molecular Function GO:0001046 (core promoter sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0031490 (chromatin DNA binding)
GO:0032452 (histone demethylase activity)
GO:0032454 (histone demethylase activity (H3-K9 specific))
GO:0034647 (histone demethylase activity (H3-trimethyl-K4 specific))
GO:0034648 (histone demethylase activity (H3-dimethyl-K4 specific))
GO:0035064 (methylated histone binding)
GO:0042393 (histone binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007275 (multicellular organism development)
GO:0007283 (spermatogenesis)
GO:0008584 (male gonad development)
GO:0032922 (circadian regulation of gene expression)
GO:0033169 (histone H3-K9 demethylation)
GO:0034720 (histone H3-K4 demethylation)
GO:0034721 (histone H3-K4 demethylation, trimethyl-H3-K4-specific)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048511 (rhythmic process)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0055114 (oxidation-reduction process)
GO:1901726 (negative regulation of histone deacetylase activity)

Target Cross References - Protein

Human Protein Atlas ENSG00000073614
IntAct P29375
Guide to Pharmacology 2680
Open Targets ENSG00000073614
Reactome R-HSA-3214842 (HDMs demethylate histones.)
UniProt A8MV76 P29375 Q4LE72 Q86XZ1

Target Cross References - Domain

InterPro IPR001606 (ARID_dom.)
IPR001965 (Znf_PHD.)
IPR003347 (JmjC_dom.)
IPR003349 (JmjN.)
IPR004198 (Znf_C5HC2.)
IPR011011 (Znf_FYVE_PHD.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR013637 (Lys_sp_deMease-like_dom.)
IPR019786 (Zinc_finger_PHD-type_CS.)
IPR019787 (Znf_PHD-finger.)
IPR036431 (ARID_dom_sf.)
Pfam PF00628 (PHD)
PF01388 (ARID)
PF02373 (JmjC)
PF02375 (JmjN)
PF02928 (zf-C5HC2)
PF08429 (PLU-1)

Target Cross References - Structure

PDBe 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T
CREDO 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T
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