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Target Report Card

Target Name and Classification

Target ID CHEMBL2409
Preferred Name Epoxide hydratase
Synonyms Bifunctional epoxide hydrolase 2 | CEH | Cytosolic epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | Lipid-phosphate phosphatase | SEH | Soluble epoxide hydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s33 family

Target Components

Component Description Relationship Accession
Bifunctional epoxide hydrolase 2 SINGLE PROTEIN P34913

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120915
Ensembl ENSG00000120915
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004301 (epoxide hydrolase activity)
GO:0005102 (receptor binding)
GO:0015643 (toxic substance binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0033885 (10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity)
GO:0042577 (lipid phosphatase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006954 (inflammatory response)
GO:0008152 (metabolic process)
GO:0008217 (regulation of blood pressure)
GO:0009636 (response to toxic substance)
GO:0010628 (positive regulation of gene expression)
GO:0016311 (dephosphorylation)
GO:0017144 (drug metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0019439 (aromatic compound catabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0046272 (stilbene catabolic process)
GO:0046839 (phospholipid dephosphorylation)
GO:0072593 (reactive oxygen species metabolic process)
GO:0090181 (regulation of cholesterol metabolic process)
GO:0097176 (epoxide metabolic process)
GO:0097755 (positive regulation of blood vessel diameter)
Wikipedia Epoxide_hydrolase_2

Target Cross References - Protein

canSAR P34913
Human Protein Atlas ENSG00000120915
IntAct P34913
Guide to Pharmacology 2970
Open Targets ENSG00000120915
PharmGKB PA27830
Reactome R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
UniProt B2Z3B1 B3KTU8 B3KUA0 G3V134 J3KPH7 P34913 Q16764 Q9HBJ1 Q9HBJ2

Target Cross References - Domain

InterPro IPR000073 (AB_hydrolase_1.)
IPR000639 (Epox_hydrolase-like.)
IPR006439 (HAD-SF_hydro_IA.)
IPR011945 (HAD-SF_ppase_IA/epoxid_hydro_N.)
IPR023198 (PGP_dom2.)
IPR023214 (HAD_sf.)
IPR029058 (AB_hydrolase.)
IPR036412 (HAD-like_sf.)
Pfam PF00561 (Abhydrolase_1)

Target Cross References - Structure

PDBe 1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 3WK4 3WK5 3WK6 3WK7 3WK8 3WK9 3WKA 3WKB 3WKC 3WKD 3WKE More...
CREDO 1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 3WK4 3WK5 3WK6 3WK7 3WK8 3WK9 3WKA 3WKB 3WKC 3WKD 3WKE More...