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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2392
Target Type SINGLE PROTEIN
Preferred Name DNA polymerase beta
Synonyms DNA polymerase beta | POLB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA polymerase beta SINGLE PROTEIN P06746

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070501
Ensembl ENSG00000070501
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005874 (microtubule)
GO:0005876 (spindle microtubule)
GO:0043234 (protein complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0003906 (DNA-(apurinic or apyrimidinic site) lyase activity)
GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016829 (lyase activity)
GO:0019899 (enzyme binding)
GO:0034061 (DNA polymerase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006260 (DNA replication)
GO:0006261 (DNA-dependent DNA replication)
GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006286 (base-excision repair, base-free sugar-phosphate removal)
GO:0006287 (base-excision repair, gap-filling)
GO:0006288 (base-excision repair, DNA ligation)
GO:0006290 (pyrimidine dimer repair)
GO:0006297 (nucleotide-excision repair, DNA gap filling)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007435 (salivary gland morphogenesis)
GO:0007568 (aging)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010332 (response to gamma radiation)
GO:0016445 (somatic diversification of immunoglobulins)
GO:0016446 (somatic hypermutation of immunoglobulin genes)
GO:0045471 (response to ethanol)
GO:0048535 (lymph node development)
GO:0048536 (spleen development)
GO:0048872 (homeostasis of number of cells)
GO:0051402 (neuron apoptotic process)
GO:0055093 (response to hyperoxia)
GO:0071707 (immunoglobulin heavy chain V-D-J recombination)
GO:0071897 (DNA biosynthetic process)
Wikipedia DNA_polymerase_beta

Target Cross References - Protein

canSAR P06746
Human Protein Atlas ENSG00000070501
IntAct P06746
Open Targets ENSG00000070501
PharmGKB PA276
Reactome R-HSA-110362 (POLB-Dependent Long Patch Base Excision Repair.)
R-HSA-110373 (Resolution of AP sites via the multiple-nucleotide patch replacement pathway.)
R-HSA-110381 (Resolution of AP sites via the single-nucleotide replacement pathway.)
R-HSA-5649702 (APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.)
R-HSA-5651801 (PCNA-Dependent Long Patch Base Excision Repair.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-73930 (Abasic sugar-phosphate removal via the single-nucleotide replacement pathway.)
UniProt B2RC78 P06746 Q3KP48 Q6FI34

Target Cross References - Domain

InterPro IPR002008 (DNA_pol_X_beta-like.)
IPR002054 (DNA-dir_DNA_pol_X.)
IPR003583 (Hlx-hairpin-Hlx_DNA-bd_motif.)
IPR010996 (DNA_pol_b-like_N.)
IPR018944 (DNA_pol_lambd_fingers_domain.)
IPR019843 (DNA_pol-X_BS.)
IPR022312 (DNA_pol_X.)
IPR027420 (PolB_N.)
IPR028207 (DNA_pol_B_palm_palm.)
IPR029398 (PolB_thumb.)
Pfam PF10391 (DNA_pol_lambd_f)
PF14716 (HHH_8)
PF14791 (DNA_pol_B_thumb)
PF14792 (DNA_pol_B_palm)

Target Cross References - Structure

PDBe 1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO More...
CREDO 1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO More...
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