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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL238
Target Type SINGLE PROTEIN
Preferred Name Dopamine transporter
Synonyms DA transporter | DAT | DAT1 | SLC6A3 | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium-dependent dopamine transporter SINGLE PROTEIN Q01959

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095201 Monoamine transporters; serotonin & dopamine SELECTIVITY GROUP
CHEMBL2096990 Monoamine transporters; Norepinephrine & dopamine SELECTIVITY GROUP
CHEMBL2363064 Monoamine transporter PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL405 AMPHETAMINE Dopamine transporter releasing agent 4 KEGG PubMed PubMed
CHEMBL501 AMPHETAMINE SULFATE Dopamine transporter releasing agent 4 KEGG PubMed PubMed
CHEMBL612 DEXTROAMPHETAMINE Dopamine transporter releasing agent 4 PubMed PubMed PubMed
CHEMBL796 METHYLPHENIDATE Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL904 DEXMETHYLPHENIDATE HYDROCHLORIDE Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL1373 MODAFINIL Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL1693 DIETHYLPROPION HYDROCHLORIDE Dopamine transporter inhibitor 4 DailyMed ISBN PubMed PubMed
CHEMBL1698 BUPROPION HYDROCHLORIDE Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL1722 METHYLPHENIDATE HYDROCHLORIDE Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL1200377 AMPHETAMINE ASPARTATE Dopamine transporter releasing agent 4 KEGG PubMed PubMed
CHEMBL1200387 AMPHETAMINE ADIPATE Dopamine transporter releasing agent 4 KEGG PubMed PubMed
CHEMBL1200483 PHENMETRAZINE HYDROCHLORIDE Dopamine transporter inhibitor 4 PubMed
CHEMBL1200782 DEXTROAMPHETAMINE ADIPATE Dopamine transporter releasing agent 4 PubMed PubMed PubMed
CHEMBL1201178 LISDEXAMFETAMINE DIMESYLATE Dopamine transporter releasing agent 4 DailyMed
CHEMBL1201192 ARMODAFINIL Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL1201735 BUPROPION HYDROBROMIDE Dopamine transporter inhibitor 4 DailyMed PubMed
CHEMBL2062163 PHENDIMETRAZINE TARTRATE Dopamine transporter inhibitor 4 FDA PubMed
CHEMBL3544971 DEXTROAMPHETAMINE SULFATE Dopamine transporter releasing agent 4 PubMed PubMed PubMed
CHEMBL3989844 DEXTROAMPHETAMINE SACCHARATE Dopamine transporter releasing agent 4 PubMed PubMed PubMed
CHEMBL2104986 TEDATIOXETINE Dopamine transporter inhibitor 2 Other Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142319 ENSG00000276996
Ensembl ENSG00000142319 ENSG00000276996
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016600 (flotillin complex)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0045121 (membrane raft)
GO:0098793 (presynapse)
GO Molecular Function GO:0002020 (protease binding)
GO:0005102 (receptor binding)
GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005329 (dopamine transmembrane transporter activity)
GO:0005330 (dopamine:sodium symporter activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0035240 (dopamine binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0047485 (protein N-terminus binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0006836 (neurotransmitter transport)
GO:0007568 (aging)
GO:0007595 (lactation)
GO:0007608 (sensory perception of smell)
GO:0007626 (locomotory behavior)
GO:0010039 (response to iron ion)
GO:0014070 (response to organic cyclic compound)
GO:0015844 (monoamine transport)
GO:0015872 (dopamine transport)
GO:0021984 (adenohypophysis development)
GO:0035094 (response to nicotine)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042220 (response to cocaine)
GO:0042416 (dopamine biosynthetic process)
GO:0042420 (dopamine catabolic process)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0051583 (dopamine uptake involved in synaptic transmission)
GO:0051591 (response to cAMP)
GO:0055085 (transmembrane transport)
GO:0060134 (prepulse inhibition)
GO:0090494 (dopamine uptake)

Target Cross References - Protein

canSAR Q01959
CGD Parkinsonism-dystonia, infantile
Human Protein Atlas ENSG00000142319 ENSG00000276996
IntAct Q01959
Guide to Pharmacology 927
MICAD NBK22986 (Dopamine transporter (DAT))
NBK23165 (Dopamine transporter)
NBK23540 (Dopamine transporter)
NBK23712 (Dopamine transporters)
Open Targets ENSG00000142319 ENSG00000276996
PharmGKB PA311
Reactome R-HSA-379401 (Dopamine clearance from the synaptic cleft.)
R-HSA-442660 (Na+/Cl- dependent neurotransmitter transporters.)
R-HSA-5619081 (Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS).)
R-HSA-5660724 (Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS).)
UniProt A2RUN4 Q01959 Q14996

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR002436 (Na/ntran_symport_dopamine.)
IPR037272 (SNS_sf.)
Pfam PF00209 (SNF)
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