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Target Report Card

Target Name and Classification

Target ID CHEMBL2372
Preferred Name Catechol O-methyltransferase
Synonyms Catechol O-methyltransferase | Comt
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Catechol O-methyltransferase SINGLE PROTEIN P22734

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043197 (dendritic spine)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0044297 (cell body)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0008168 (methyltransferase activity)
GO:0008171 (O-methyltransferase activity)
GO:0016206 (catechol O-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0102084 (L-dopa O-methyltransferase activity)
GO:0102938 (orcinol O-methyltransferase activity)
GO Biological Process GO:0006584 (catecholamine metabolic process)
GO:0007565 (female pregnancy)
GO:0007612 (learning)
GO:0007614 (short-term memory)
GO:0008210 (estrogen metabolic process)
GO:0009712 (catechol-containing compound metabolic process)
GO:0014070 (response to organic cyclic compound)
GO:0016036 (cellular response to phosphate starvation)
GO:0032259 (methylation)
GO:0032496 (response to lipopolysaccharide)
GO:0032502 (developmental process)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0042135 (neurotransmitter catabolic process)
GO:0042417 (dopamine metabolic process)
GO:0042420 (dopamine catabolic process)
GO:0042424 (catecholamine catabolic process)
GO:0042493 (response to drug)
GO:0043627 (response to estrogen)
GO:0045963 (negative regulation of dopamine metabolic process)
GO:0046498 (S-adenosylhomocysteine metabolic process)
GO:0046500 (S-adenosylmethionine metabolic process)
GO:0048265 (response to pain)
GO:0048609 (multicellular organismal reproductive process)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0050668 (positive regulation of homocysteine metabolic process)
GO:0051930 (regulation of sensory perception of pain)

Target Cross References - Protein

canSAR P22734
Guide to Pharmacology 2472
Reactome R-RNO-156581 (Methylation.)
R-RNO-379397 (Enzymatic degradation of dopamine by COMT.)
R-RNO-379398 (Enzymatic degradation of Dopamine by monoamine oxidase.)
UniProt P22734

Target Cross References - Domain

InterPro IPR002935 (O-MeTrfase_3.)
IPR017128 (Catechol_O-MeTrfase_euk.)
IPR029063 (SAM-dependent_MTases.)
Pfam PF01596 (Methyltransf_3)

Target Cross References - Structure

PDBe 1H1D 1JR4 1VID 2CL5 2ZLB 2ZTH 2ZVJ 3A7D 3HVH 3HVI 3HVJ 3HVK 3NW9 3NWB 3NWE 3OE4 3OE5 3OZR 3OZS 3OZT 3R6T 3S68 3U81 4P7G More...
CREDO 1H1D 1JR4 1VID 2CL5 2ZLB 2ZTH 2ZVJ 3A7D 3HVH 3HVI 3HVJ 3HVK 3NW9 3NWB 3NWE 3OE4 3OE5 3OZR 3OZS 3OZT 3R6T 3S68 3U81 4P7G More...