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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2366505
Target Type SINGLE PROTEIN
Preferred Name Integrase
Synonyms Integrase
Organism Human immunodeficiency virus 1
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Integrase SINGLE PROTEIN Q76353

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003824 (catalytic activity)
GO:0003964 (RNA-directed DNA polymerase activity)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006278 (RNA-dependent DNA biosynthetic process)
GO:0006310 (DNA recombination)
GO:0008152 (metabolic process)
GO:0015074 (DNA integration)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)

Target Cross References - Protein

IntAct Q76353
UniProt Q76353

Target Cross References - Domain

InterPro IPR001037 (Integrase_C_retrovir.)
IPR001584 (Integrase_cat-core.)
IPR003308 (Integrase_Zn-bd_dom_N.)
IPR012337 (RNaseH-like_sf.)
IPR017856 (Integrase-like_N.)
IPR036397 (RNaseH_sf.)
IPR036862 (Integrase_C_dom_sf_retrovir.)
Pfam PF00552 (IN_DBD_C)
PF00665 (rve)
PF02022 (Integrase_Zn)

Target Cross References - Structure

PDBe 1HYV 1HYZ 3LPT 3LPU 3ZCM 3ZSO 3ZSQ 3ZSR 3ZSV 3ZSW 3ZSX 3ZSY 3ZSZ 3ZT0 3ZT1 3ZT2 3ZT3 3ZT4 4CE9 4CEA 4CEB 4CEC 4CED 4CEE More...
CREDO 1HYV 1HYZ 3LPT 3LPU 3ZCM 3ZSO 3ZSQ 3ZSR 3ZSV 3ZSW 3ZSX 3ZSY 3ZSZ 3ZT0 3ZT1 3ZT2 3ZT3 3ZT4 4CE9 4CEA 4CEB 4CEC 4CED 4CEE More...
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