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Target Report Card

Target Name and Classification

Target ID CHEMBL2366456
Preferred Name Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Organism Cavia porcellus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1C SINGLE PROTEIN O35505

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3988633 L-type calcium channel PROTEIN FAMILY
CHEMBL3988638 Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0061337 (cardiac conduction)
GO:0061577 (calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:0070588 (calcium ion transmembrane transport)

Target Cross References - Protein

UniProt O35505

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005452 (LVDCC_a1dsu.)
IPR005821 (Ion_trans_dom.)
Pfam PF00520 (Ion_trans)