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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2364701
Target Type PROTEIN COMPLEX
Preferred Name 26S proteosome
Synonyms
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > threonine protease > threonine protease pbt clan > threonine protease t1a subfamily
  • other cytosolic protein
  • unclassified protein

Target Components

Component Description Relationship Accession
Proteasome subunit beta type-2 PROTEIN SUBUNIT P49721
Proteasome subunit beta type-1 PROTEIN SUBUNIT P20618
Proteasome subunit beta type-5 PROTEIN SUBUNIT P28074
Proteasome subunit beta type-8 PROTEIN SUBUNIT P28062
Proteasome subunit beta type-9 PROTEIN SUBUNIT P28065
Proteasome subunit beta type-6 PROTEIN SUBUNIT P28072
Proteasome subunit alpha type-1 PROTEIN SUBUNIT P25786
Proteasome subunit alpha type-2 PROTEIN SUBUNIT P25787
Proteasome subunit alpha type-3 PROTEIN SUBUNIT P25788
Proteasome subunit alpha type-4 PROTEIN SUBUNIT P25789
Proteasome subunit alpha type-5 PROTEIN SUBUNIT P28066
Proteasome subunit alpha type-6 PROTEIN SUBUNIT P60900
Proteasome subunit alpha type-7 PROTEIN SUBUNIT O14818
Proteasome subunit alpha type-7-like PROTEIN SUBUNIT Q8TAA3
Proteasome subunit beta type-10 PROTEIN SUBUNIT P40306
Proteasome subunit beta type-11 PROTEIN SUBUNIT A5LHX3
Proteasome subunit beta type-3 PROTEIN SUBUNIT P49720
Proteasome subunit beta type-4 PROTEIN SUBUNIT P28070
Proteasome subunit beta type-7 PROTEIN SUBUNIT Q99436
26S proteasome non-ATPase regulatory subunit 1 PROTEIN SUBUNIT Q99460
26S proteasome non-ATPase regulatory subunit 14 PROTEIN SUBUNIT O00487
Proteasomal ubiquitin receptor ADRM1 PROTEIN SUBUNIT Q16186
26S proteasome regulatory subunit 7 PROTEIN SUBUNIT P35998
26S proteasome regulatory subunit 4 PROTEIN SUBUNIT P62191
26S proteasome regulatory subunit 6B PROTEIN SUBUNIT P43686
26S proteasome regulatory subunit 10B PROTEIN SUBUNIT P62333
26S proteasome regulatory subunit 6A PROTEIN SUBUNIT P17980
26S proteasome regulatory subunit 8 PROTEIN SUBUNIT P62195
26S proteasome non-ATPase regulatory subunit 2 PROTEIN SUBUNIT Q13200
26S proteasome non-ATPase regulatory subunit 3 PROTEIN SUBUNIT O43242
26S proteasome non-ATPase regulatory subunit 12 PROTEIN SUBUNIT O00232
26S proteasome non-ATPase regulatory subunit 11 PROTEIN SUBUNIT O00231
26S proteasome non-ATPase regulatory subunit 6 PROTEIN SUBUNIT Q15008
26S proteasome non-ATPase regulatory subunit 7 PROTEIN SUBUNIT P51665
26S proteasome non-ATPase regulatory subunit 13 PROTEIN SUBUNIT Q9UNM6
26S proteasome non-ATPase regulatory subunit 4 PROTEIN SUBUNIT P55036
26S proteasome non-ATPase regulatory subunit 8 PROTEIN SUBUNIT P48556
26S proteasome complex subunit SEM1 PROTEIN SUBUNIT P60896

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3492 Proteasome Macropain subunit SINGLE PROTEIN
CHEMBL3317334 Proteasome subunit beta type-10 SINGLE PROTEIN
CHEMBL4662 Proteasome Macropain subunit MB1 SINGLE PROTEIN
CHEMBL4208 Proteasome component C5 SINGLE PROTEIN
CHEMBL3831201 20S proteosome PROTEIN COMPLEX
CHEMBL5620 Proteasome subunit beta type-8 SINGLE PROTEIN
CHEMBL2007629 26S proteasome non-ATPase regulatory subunit 14 SINGLE PROTEIN
CHEMBL3885625 Proteasome subunit beta type-1/beta type-5 PROTEIN FAMILY
CHEMBL3308923 Proteasome subunit beta type-3 SINGLE PROTEIN
CHEMBL1944495 Proteasome subunit beta type-9 SINGLE PROTEIN
CHEMBL3347256 Proteasome subunit beta type-7 SINGLE PROTEIN
CHEMBL1944496 Proteasome subunit beta type-6 SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL325041 BORTEZOMIB 26S proteosome inhibitor 4 DailyMed PubMed
CHEMBL451887 CARFILZOMIB 26S proteosome inhibitor 4 FDA PubMed
CHEMBL3545432 IXAZOMIB CITRATE 26S proteosome inhibitor 4 DailyMed
CHEMBL2103884 OPROZOMIB 26S proteosome inhibitor 1 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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