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Target Report Card

Target Name and Classification

Target ID CHEMBL2364668
Target Type SINGLE PROTEIN
Preferred Name Bacterial dihydropteroate synthase
Synonyms DHPS | Dihydropteroate pyrophosphorylase | Dihydropteroate synthase | dhpS | folP
Organism Bacteria
Species Group Yes
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Dihydropteroate synthase SINGLE PROTEIN P0AC13

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL4032 Dihydropteroate synthase SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL21 SULFANILAMIDE Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed PubMed
CHEMBL437 SULFATHIAZOLE Bacterial dihydropteroate synthase inhibitor 4 PubMed
CHEMBL438 SULFAMERAZINE Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed PubMed
CHEMBL439 SULFADIAZINE Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed
CHEMBL443 SULFAMETHOXAZOLE Bacterial dihydropteroate synthase inhibitor 4 PubMed
CHEMBL446 SULFAMETHAZINE Bacterial dihydropteroate synthase inhibitor 4 ISBN PubMed PubMed PubMed PubMed
CHEMBL453 SULFISOXAZOLE Bacterial dihydropteroate synthase inhibitor 4 PubMed
CHEMBL268869 SULFAMETHOXYPYRIDAZINE Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed PubMed
CHEMBL455 SULFACETAMIDE Bacterial dihydropteroate synthase inhibitor 4 KEGG PubMed PubMed
CHEMBL700 SULFAPYRIDINE Bacterial dihydropteroate synthase inhibitor 4 ISBN
CHEMBL62193 SULFADIMETHOXINE Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed
CHEMBL1109 SULFAPHENAZOLE Bacterial dihydropteroate synthase inhibitor 4 PubMed
CHEMBL1191 SULFAMETHIZOLE Bacterial dihydropteroate synthase inhibitor 4 KEGG PubMed
CHEMBL1200321 SULFISOXAZOLE DIOLAMINE Bacterial dihydropteroate synthase inhibitor 4 PubMed
CHEMBL1200351 SULFADIAZINE SODIUM Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed
CHEMBL1200359 SULFAMETER Bacterial dihydropteroate synthase inhibitor 4 ISBN PubMed
CHEMBL1200910 SULFISOXAZOLE ACETYL Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed PubMed
CHEMBL1201161 MAFENIDE ACETATE Bacterial dihydropteroate synthase inhibitor 4 FDA ISBN PubMed
CHEMBL1382627 SULFADIAZINE, SILVER Bacterial dihydropteroate synthase inhibitor 4 DailyMed
CHEMBL1525826 SULFALENE Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed
CHEMBL1723241 SULFACETAMIDE SODIUM Bacterial dihydropteroate synthase inhibitor 4 KEGG PubMed PubMed
CHEMBL2107253 SULFADIMETHOXINE SODIUM Bacterial dihydropteroate synthase inhibitor 4 PubMed PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004156 (dihydropteroate synthase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0009396 (folic acid-containing compound biosynthetic process)
GO:0042493 (response to drug)
GO:0042558 (pteridine-containing compound metabolic process)
GO:0044237 (cellular metabolic process)
GO:0046654 (tetrahydrofolate biosynthetic process)
GO:0046656 (folic acid biosynthetic process)

Target Cross References - Protein

IntAct P0AC13
UniProt P0AC13 P26282 P78110 Q2M935

Target Cross References - Domain

InterPro IPR000489 (Pterin-binding_dom.)
IPR006390 (DHP_synth.)
IPR011005 (Dihydropteroate_synth-like.)
Pfam PF00809 (Pterin_bind)

Target Cross References - Structure

PDBe 1AJ0 1AJ2 1AJZ
CREDO 1AJ0 1AJ2 1AJZ
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