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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2364026
Target Type SINGLE PROTEIN
Preferred Name Pyruvate:ferredoxin oxidoreductase
Synonyms CpPNO | PFOR | Pyruvate dehydrogenase [NADP(+)] | Pyruvate:NADP(+) oxidoreductase
Organism Cryptosporidium parvum
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Pyruvate dehydrogenase [NADP(+)] SINGLE PROTEIN Q968X7

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1401 NITAZOXANIDE Pyruvate:ferredoxin oxidoreductase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0005506 (iron ion binding)
GO:0010181 (FMN binding)
GO:0016491 (oxidoreductase activity)
GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors)
GO:0030976 (thiamine pyrophosphate binding)
GO:0046872 (metal ion binding)
GO:0050243 (pyruvate dehydrogenase (NADP+) activity)
GO:0051536 (iron-sulfur cluster binding)
GO:0051539 (4 iron, 4 sulfur cluster binding)
GO Biological Process GO:0006090 (pyruvate metabolic process)
GO:0008152 (metabolic process)
GO:0022900 (electron transport chain)
GO:0045333 (cellular respiration)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

UniProt Q968X7

Target Cross References - Domain

InterPro IPR001094 (Flavdoxin-like.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR002869 (Pyrv_flavodox_OxRed_cen.)
IPR002880 (Pyrv_Fd/Flavodoxin_OxRdtase_N.)
IPR003097 (FAD-binding_1.)
IPR008254 (Flavodoxin/NO_synth.)
IPR009014 (Transketo_C/PFOR_II.)
IPR011766 (TPP_enzyme-bd_C.)
IPR011895 (Pyrv_flavodox_OxRed.)
IPR017896 (4Fe4S_Fe-S-bd.)
IPR017900 (4Fe4S_Fe_S_CS.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR019456 (Pyrv-flavodox_OxRtase_EKR.)
IPR019752 (Pyrv/ketoisovalerate_OxRed_cat.)
IPR023173 (NADPH_Cyt_P450_Rdtase_dom3.)
IPR029039 (Flavoprotein-like_dom.)
IPR029061 (THDP-binding.)
IPR033412 (PFOR_II.)
Pfam PF00175 (NAD_binding_1)
PF00258 (Flavodoxin_1)
PF00667 (FAD_binding_1)
PF01558 (POR)
PF01855 (POR_N)
PF02775 (TPP_enzyme_C)
PF10371 (EKR)
PF12838 (Fer4_7)
PF17147 (PFOR_II)
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