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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2363070
Target Type PROTEIN FAMILY
Preferred Name Retinoid X receptor
Synonyms NR2B1 | NR2B2 | NR2B3 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 2 group B member 2 | Nuclear receptor subfamily 2 group B member 3 | RXRA | RXRB | RXRG | Retinoic acid receptor RXR-alpha | Retinoic acid receptor RXR-beta | Retinoic acid receptor RXR-gamma | Retinoid X receptor alpha | Retinoid X receptor beta | Retinoid X receptor gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 2
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 1
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 3

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-alpha GROUP MEMBER P19793
Retinoic acid receptor RXR-beta GROUP MEMBER P28702
Retinoic acid receptor RXR-gamma GROUP MEMBER P48443

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111394 RXR alpha/PPAR gamma PROTEIN COMPLEX
CHEMBL3430878 Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta PROTEIN COMPLEX
CHEMBL3885613 Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha PROTEIN COMPLEX
CHEMBL3430879 Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha PROTEIN COMPLEX
CHEMBL2363072 Retinoid X receptor gamma/retinoic acid receptor alpha PROTEIN COMPLEX
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY
CHEMBL3430883 Retinoic acid receptor alpha/Retinoid X receptor alpha PROTEIN COMPLEX
CHEMBL2004 Retinoid X receptor gamma SINGLE PROTEIN
CHEMBL2061 Retinoid X receptor alpha SINGLE PROTEIN
CHEMBL1870 Retinoid X receptor beta SINGLE PROTEIN
CHEMBL3885631 Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta PROTEIN COMPLEX
CHEMBL3885633 Retinoic acid receptor RXR-alpha/gamma PROTEIN COMPLEX
CHEMBL3885632 Retinoic acid receptor RXR-alpha/Vitamin D3 receptor PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1023 BEXAROTENE Retinoid X receptor agonist 4 FDA
CHEMBL75133 IRX-4204 Retinoid X receptor agonist 2 Other Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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