ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2363032
Target Type PROTEIN COMPLEX GROUP
Preferred Name Voltage-gated calcium channel
Synonyms
Organism Homo sapiens
Species Group No
Protein Target Classification
  • auxiliary transport protein > calcium channel auxiliary subunit alpha2delta family
  • auxiliary transport protein > calcium channel auxiliary subunit gamma family
  • auxiliary transport protein > calcium channel auxiliary subunit beta family
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1C GROUP MEMBER Q13936
Voltage-dependent L-type calcium channel subunit alpha-1D GROUP MEMBER Q01668
Voltage-dependent L-type calcium channel subunit alpha-1F GROUP MEMBER O60840
Voltage-dependent L-type calcium channel subunit alpha-1S GROUP MEMBER Q13698
Voltage-dependent N-type calcium channel subunit alpha-1B GROUP MEMBER Q00975
Voltage-dependent P/Q-type calcium channel subunit alpha-1A GROUP MEMBER O00555
Voltage-dependent R-type calcium channel subunit alpha-1E GROUP MEMBER Q15878
Voltage-dependent T-type calcium channel subunit alpha-1G GROUP MEMBER O43497
Voltage-dependent T-type calcium channel subunit alpha-1H GROUP MEMBER O95180
Voltage-dependent T-type calcium channel subunit alpha-1I GROUP MEMBER Q9P0X4
Voltage-dependent calcium channel subunit alpha-2/delta-1 GROUP MEMBER P54289
Voltage-dependent calcium channel subunit alpha-2/delta-2 GROUP MEMBER Q9NY47
Voltage-dependent calcium channel subunit alpha-2/delta-3 GROUP MEMBER Q8IZS8
Voltage-dependent calcium channel subunit alpha-2/delta-4 GROUP MEMBER Q7Z3S7
Voltage-dependent L-type calcium channel subunit beta-2 GROUP MEMBER Q08289
Voltage-dependent L-type calcium channel subunit beta-1 GROUP MEMBER Q02641
Voltage-dependent L-type calcium channel subunit beta-3 GROUP MEMBER P54284
Voltage-dependent calcium channel gamma-7 subunit GROUP MEMBER P62955
Voltage-dependent calcium channel gamma-5 subunit GROUP MEMBER Q9UF02
Voltage-dependent calcium channel gamma-2 subunit GROUP MEMBER Q9Y698
Voltage-dependent calcium channel gamma-4 subunit GROUP MEMBER Q9UBN1
Voltage-dependent calcium channel gamma-8 subunit GROUP MEMBER Q8WXS5
Voltage-dependent calcium channel gamma-3 subunit GROUP MEMBER O60359
Voltage-dependent calcium channel gamma-6 subunit GROUP MEMBER Q9BXT2
Voltage-dependent calcium channel gamma-1 subunit GROUP MEMBER Q06432
Voltage-dependent L-type calcium channel subunit beta-4 GROUP MEMBER O00305

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095229 Voltage-gated L-type calcium channel PROTEIN FAMILY
CHEMBL4266 Voltage-gated P/Q-type calcium channel alpha-1A subunit SINGLE PROTEIN
CHEMBL3805 Voltage-gated L-type calcium channel alpha-1S subunit SINGLE PROTEIN
CHEMBL5558 Voltage-gated T-type calcium channel alpha-1I subunit SINGLE PROTEIN
CHEMBL1859 Voltage-gated T-type calcium channel alpha-1H subunit SINGLE PROTEIN
CHEMBL4641 Voltage-gated T-type calcium channel alpha-1G subunit SINGLE PROTEIN
CHEMBL1940 Voltage-gated L-type calcium channel alpha-1C subunit SINGLE PROTEIN
CHEMBL2362995 Voltage-gated T-type calcium channel PROTEIN FAMILY
CHEMBL4478 Voltage-gated N-type calcium channel alpha-1B subunit SINGLE PROTEIN
CHEMBL2097170 Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 PROTEIN-PROTEIN INTERACTION
CHEMBL3317336 Voltage-dependent L-type calcium channel subunit beta-2 SINGLE PROTEIN
CHEMBL4138 Voltage-gated L-type calcium channel alpha-1D subunit SINGLE PROTEIN
CHEMBL1919 Voltage-gated calcium channel alpha2/delta subunit 1 SINGLE PROTEIN
CHEMBL3896 Voltage-gated calcium channel alpha2/delta subunit 2 SINGLE PROTEIN
CHEMBL1687682 Voltage-dependent R-type calcium channel subunit alpha-1E SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL940 GABAPENTIN Voltage-gated calcium channel modulator 4 FDA ISBN PubMed
CHEMBL1059 PREGABALIN Voltage-gated calcium channel modulator 4 FDA PubMed
CHEMBL1200382 BEPRIDIL HYDROCHLORIDE Voltage-gated calcium channel blocker 4 ISBN PubMed
CHEMBL1628502 GABAPENTIN ENACARBIL Voltage-gated calcium channel modulator 4 DailyMed FDA PubMed
CHEMBL2103836 IMAGABALIN Voltage-gated calcium channel modulator 3
CHEMBL593430 ATAGABALIN Voltage-gated calcium channel modulator 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

spacer
spacer