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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2362988
Target Type SINGLE PROTEIN
Preferred Name Acetylcholinesterase
Synonyms Ace1 | Carboxylic ester hydrolase
Organism Pediculus humanus capitis
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Carboxylic ester hydrolase SINGLE PROTEIN A2PZ98

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200468 MALATHION Acetylcholinesterase inhibitor 4 DailyMed FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043083 (synaptic cleft)
GO Molecular Function GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001507 (acetylcholine catabolic process in synaptic cleft)

Target Cross References - Protein

UniProt A2PZ98

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR001445 (Acylcholinesterase_insect.)
IPR002018 (CarbesteraseB.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
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