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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2362985
Preferred Name Voltage-sensitive sodium channel
Synonyms Sodium channel protein | vssc
Organism Sarcoptes scabiei type hominis
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein SINGLE PROTEIN Q2VKV7

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1525 PERMETHRIN Voltage-sensitive sodium channel blocker 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0005509 (calcium ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0034220 (ion transmembrane transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0060078 (regulation of postsynaptic membrane potential)

Target Cross References - Protein

UniProt Q2VKV7

Target Cross References - Domain

InterPro IPR001696 (Na_channel_asu.)
IPR002048 (EF_hand_dom.)
IPR005821 (Ion_trans_dom.)
IPR010526 (Na_trans_assoc.)
IPR027359 (Channel_four-helix_dom.)
IPR028821 (Na_channel_a11su.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)