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Target Report Card

Target Name and Classification

Target ID CHEMBL2354204
Target Type PROTEIN FAMILY
Preferred Name Bacterial penicillin-binding protein
Synonyms Beta-lactamase | D-alanyl-D-alanine carboxypeptidase DacA | D-alanyl-D-alanine carboxypeptidase DacB | D-alanyl-D-alanine carboxypeptidase DacC | D-alanyl-D-alanine endopeptidase | DD-carboxypeptidase | DD-carboxypeptidase | DD-carboxypeptidase | DD-endopeptidase | DD-peptidase | DD-peptidase | DD-peptidase | DD-transpeptidase | DD-transpeptidase | Essential cell division protein FtsI | Murein polymerase | Murein transpeptidase | PBP-1a | PBP-1b | PBP-2 | PBP-3 | PBP-4 | PBP-5 | PBP-6 | PBP1a | PBP1b | Penicillin-binding protein 1A | Penicillin-binding protein 1B | Penicillin-binding protein 2 | Penicillin-binding protein 3 | Penicillin-binding protein 4 | Penicillin-binding protein 5 | Penicillin-binding protein 6 | Penicillin-insensitive transglycosylase | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Penicillin-sensitive transpeptidase | Peptidoglycan D,D-transpeptidase FtsI | Peptidoglycan D,D-transpeptidase MrdA | Peptidoglycan TGase | Peptidoglycan TGase | Peptidoglycan glycosyltransferase | Peptidoglycan synthase FtsI | Synonyms=pbpA {ECO:0000303|PubMed:3533535 | dacA | dacB | dacC | ftsI | mrcA | mrcB | mrdA | pbpF | pfv | ponA | ponB
Organism Bacteria
Species Group Yes
Protein Target Classification
  • enzyme > protease > serine protease > serine protease se clan > serine protease s11 family
  • enzyme > protease > serine protease > serine protease se clan > serine protease s13 family
  • enzyme > protease > serine protease > serine protease unclassified

Target Components

Component Description Relationship Accession
Penicillin-binding protein 1A GROUP MEMBER P02918
Penicillin-binding protein 1B GROUP MEMBER P02919
D-alanyl-D-alanine carboxypeptidase DacC GROUP MEMBER P08506
Peptidoglycan D,D-transpeptidase MrdA GROUP MEMBER P0AD65
Peptidoglycan D,D-transpeptidase FtsI GROUP MEMBER P0AD68
D-alanyl-D-alanine carboxypeptidase DacA GROUP MEMBER P0AEB2
D-alanyl-D-alanine carboxypeptidase DacB GROUP MEMBER P24228

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1813 Penicillin-binding protein 1A SINGLE PROTEIN
CHEMBL1814 Penicillin-binding protein 1B SINGLE PROTEIN
CHEMBL2354313 Bacterial penicillin-binding protein 2 SINGLE PROTEIN
CHEMBL1840 Penicillin-binding protein 2 SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL615 PENICILLIN V Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL127 MEROPENEM Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL158 AZTREONAM Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL44354 CEFTAZIDIME Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL927 CEFDINIR Bacterial penicillin-binding protein inhibitor 4 DailyMed PubMed PubMed
CHEMBL65794 CEFPIROME Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL1010 CEFOTAXIME SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1082 AMOXICILLIN Bacterial penicillin-binding protein inhibitor 4 ISBN
CHEMBL1126 PENICILLIN G SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed
CHEMBL1146 CEFAMANDOLE Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL1223 PENICILLIN G POTASSIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed
CHEMBL1232 ERTAPENEM SODIUM Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL174 AMPICILLIN Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1541 CEFIXIME Bacterial penicillin-binding protein inhibitor 4 DailyMed PubMed PubMed
CHEMBL1604 CEPHRADINE Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1605 CEFTIBUTEN Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL491571 DORIPENEM Bacterial penicillin-binding protein inhibitor 4 FDA
CHEMBL1618 CEFAMANDOLE NAFATE Bacterial penicillin-binding protein inhibitor 4 ISBN ISBN
CHEMBL1632 CEPHALOTHIN SODIUM Bacterial penicillin-binding protein inhibitor 4 ISBN PubMed
CHEMBL1644 CEFADROXIL Bacterial penicillin-binding protein inhibitor 4 DailyMed PubMed
CHEMBL454446 CEFDITOREN PIVOXIL Bacterial penicillin-binding protein inhibitor 4 FDA PubMed
CHEMBL606260 CARBENICILLIN DISODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL43708 IMIPENEM Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL1095930 CEFUROXIME AXETIL Bacterial penicillin-binding protein inhibitor 4 DailyMed KEGG PubMed
CHEMBL1200356 CYCLACILLIN Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200357 MOXALACTAM DISODIUM Bacterial penicillin-binding protein inhibitor 4 ISBN ISBN
CHEMBL1200366 CEPHALEXIN HYDROCHLORIDE Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200482 CEFOPERAZONE SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200523 CEFAZOLIN SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed
CHEMBL1200530 CEFOXITIN SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed
CHEMBL1200544 CEPHALEXIN Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200589 CEFOTIAM HYDROCHLORIDE Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200610 LORACARBEF Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL1200672 CEFPIRAMIDE SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed
CHEMBL1200758 AMPICILLIN SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200768 CEFTAZIDIME SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200820 PIPERACILLIN SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200852 PENICILLIN V POTASSIUM Bacterial penicillin-binding protein inhibitor 4 DailyMed
CHEMBL1200855 TICARCILLIN DISODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200962 CEFEPIME HYDROCHLORIDE Bacterial penicillin-binding protein inhibitor 4 DailyMed PubMed
CHEMBL1200965 BACAMPICILLIN HYDROCHLORIDE Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed
CHEMBL1200971 CEPHALOGLYCIN Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1200991 CARBENICILLIN INDANYL SODIUM Bacterial penicillin-binding protein inhibitor 4 FDA PubMed PubMed PubMed
CHEMBL1201005 CEFONICID SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1201016 CEFPODOXIME PROXETIL Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1201018 CEFACLOR Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1201019 CEFTIZOXIME SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed
CHEMBL1201043 CEPHAPIRIN SODIUM Bacterial penicillin-binding protein inhibitor 4 DailyMed ISBN
CHEMBL1201046 CEFORANIDE Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed
CHEMBL1201098 CEFOTETAN DISODIUM Bacterial penicillin-binding protein inhibitor 4 FDA PubMed
CHEMBL1201118 CEFMETAZOLE SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL1213250 CEFTOLOZANE SULFATE Bacterial penicillin-binding protein inhibitor 4 FDA
CHEMBL1697708 MEZLOCILLIN SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed
CHEMBL2146124 CEFUROXIME SODIUM Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL2303613 CEFODIZIME Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL3183193 CEFMENOXIME HYDROCHLORIDE Bacterial penicillin-binding protein inhibitor 4 PubMed
CHEMBL3183968 CEFTRIAXONE SODIUM Bacterial penicillin-binding protein inhibitor 4 DailyMed PubMed
CHEMBL3184906 CEFPROZIL Bacterial penicillin-binding protein inhibitor 4 DailyMed PubMed
CHEMBL3351077 CEFSULODIN Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL3544973 CEFTAROLINE FOSAMIL ACETATE Bacterial penicillin-binding protein inhibitor 4 FDA
CHEMBL3989515 PENICILLIN G BENZATHINE Bacterial penicillin-binding protein inhibitor 4 PubMed PubMed PubMed
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Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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