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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL234
Target Type SINGLE PROTEIN
Preferred Name Dopamine D3 receptor
Synonyms D(3) dopamine receptor | DRD3 | Dopamine D3 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(3) dopamine receptor SINGLE PROTEIN P35462

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095169 Dopamine receptors; D2 & D3 SELECTIVITY GROUP
CHEMBL2331075 D2-like dopamine receptor PROTEIN FAMILY
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY
CHEMBL2097165 Dopamine receptors; D3 & D4 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL908 CHLORPROTHIXENE Dopamine D3 receptor antagonist 4 PubMed
CHEMBL1009 LEVODOPA Dopamine D3 receptor agonist 4 DailyMed PubMed PubMed PubMed
CHEMBL2024517 CARIPRAZINE HYDROCHLORIDE Dopamine D3 receptor modulator 4 PubMed
CHEMBL2146110 SARIZOTAN HYDROCHLORIDE Dopamine D3 receptor agonist 3 PubMed PubMed
CHEMBL1823681 ETILEVODOPA Dopamine D3 receptor agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151577
Ensembl ENSG00000151577
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030139 (endocytic vesicle)
GO:0042995 (cell projection)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0019904 (protein domain specific binding)
GO:0031748 (D1 dopamine receptor binding)
GO:0035240 (dopamine binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0002016 (regulation of blood volume by renin-angiotensin)
GO:0002031 (G-protein coupled receptor internalization)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006914 (autophagy)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007611 (learning or memory)
GO:0007612 (learning)
GO:0007626 (locomotory behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0008542 (visual learning)
GO:0014059 (regulation of dopamine secretion)
GO:0019216 (regulation of lipid metabolic process)
GO:0030814 (regulation of cAMP metabolic process)
GO:0032416 (negative regulation of sodium:proton antiporter activity)
GO:0032467 (positive regulation of cytokinesis)
GO:0032922 (circadian regulation of gene expression)
GO:0034776 (response to histamine)
GO:0035176 (social behavior)
GO:0035483 (gastric emptying)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0040012 (regulation of locomotion)
GO:0040014 (regulation of multicellular organism growth)
GO:0042220 (response to cocaine)
GO:0042417 (dopamine metabolic process)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043278 (response to morphine)
GO:0045187 (regulation of circadian sleep/wake cycle, sleep)
GO:0045471 (response to ethanol)
GO:0045776 (negative regulation of blood pressure)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046717 (acid secretion)
GO:0048148 (behavioral response to cocaine)
GO:0048715 (negative regulation of oligodendrocyte differentiation)
GO:0050482 (arachidonic acid secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0050883 (musculoskeletal movement, spinal reflex action)
GO:0051584 (regulation of dopamine uptake involved in synaptic transmission)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0060134 (prepulse inhibition)
GO:0060160 (negative regulation of dopamine receptor signaling pathway)
GO:0060161 (positive regulation of dopamine receptor signaling pathway)
GO:0090325 (regulation of locomotion involved in locomotory behavior)
Wikipedia Dopamine_receptor_D3

Target Cross References - Protein

canSAR P35462
Human Protein Atlas ENSG00000151577
IntAct P35462
Guide to Pharmacology 216
Open Targets ENSG00000151577
PharmGKB PA27479
Pharos P35462 (Tclin)
Reactome R-HSA-390651 (Dopamine receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A1A4V5 P35462 Q4VBM8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001620 (Dopamine_D3_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 3PBL
CREDO 3PBL
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