ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2331075
Target Type PROTEIN FAMILY
Preferred Name D2-like dopamine receptor
Synonyms D(2) dopamine receptor | D(2C) dopamine receptor | D(3) dopamine receptor | D(4) dopamine receptor | DRD2 | DRD3 | DRD4 | Dopamine D2 receptor | Dopamine D3 receptor | Dopamine D4 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(2) dopamine receptor GROUP MEMBER P14416
D(3) dopamine receptor GROUP MEMBER P35462
D(4) dopamine receptor GROUP MEMBER P21917

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111341 Dopamine D1 and D2 receptor SELECTIVITY GROUP
CHEMBL3038478 Dopamine receptor D2L/neurotensin receptor NTS1 PROTEIN COMPLEX
CHEMBL234 Dopamine D3 receptor SINGLE PROTEIN
CHEMBL2095169 Dopamine receptors; D2 & D3 SELECTIVITY GROUP
CHEMBL2111468 Dopamine D2 receptor and serotonin 2a receptor SELECTIVITY GROUP
CHEMBL2095396 Dopamine receptors; D2 & D4 SELECTIVITY GROUP
CHEMBL217 Dopamine D2 receptor SINGLE PROTEIN
CHEMBL2111460 Dopamine D2 receptor and serotonin 1a receptor SELECTIVITY GROUP
CHEMBL219 Dopamine D4 receptor SINGLE PROTEIN
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY
CHEMBL2097165 Dopamine receptors; D3 & D4 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL54 HALOPERIDOL D2-like dopamine receptor inverse agonist 4 ISBN PubMed
CHEMBL479 THIORIDAZINE D2-like dopamine receptor antagonist 4 DailyMed ISBN
CHEMBL71 CHLORPROMAZINE D2-like dopamine receptor antagonist 4 ISBN PubMed
CHEMBL715 OLANZAPINE D2-like dopamine receptor antagonist 4 FDA
CHEMBL831 LOXAPINE D2-like dopamine receptor antagonist 4 FDA
CHEMBL1108 DROPERIDOL D2-like dopamine receptor antagonist 4 PubMed
CHEMBL1303 ROTIGOTINE D2-like dopamine receptor agonist 4 FDA
CHEMBL1616 APOMORPHINE HYDROCHLORIDE D2-like dopamine receptor agonist 4 DailyMed ISBN
CHEMBL1713 CHLORPROMAZINE HYDROCHLORIDE D2-like dopamine receptor antagonist 4 ISBN PubMed
CHEMBL1764 LEVOMEPROMAZINE D2-like dopamine receptor antagonist 4 ISBN
CHEMBL1200411 ROPINIROLE HYDROCHLORIDE D2-like dopamine receptor agonist 4 DailyMed
CHEMBL1200469 PROMAZINE HYDROCHLORIDE D2-like dopamine receptor antagonist 4 ISBN ISBN
CHEMBL1200503 BROMOCRIPTINE MESYLATE D2-like dopamine receptor agonist 4 DailyMed PubMed
CHEMBL1200916 THIORIDAZINE HYDROCHLORIDE D2-like dopamine receptor antagonist 4 DailyMed ISBN
CHEMBL1200986 HALOPERIDOL DECANOATE D2-like dopamine receptor inverse agonist 4 DailyMed ISBN PubMed
CHEMBL1201060 LOXAPINE HYDROCHLORIDE D2-like dopamine receptor antagonist 4 FDA
CHEMBL1201155 LOXAPINE SUCCINATE D2-like dopamine receptor antagonist 4 FDA
CHEMBL1257040 TRIFLUOPERAZINE HYDROCHLORIDE D2-like dopamine receptor antagonist 4 ISBN
CHEMBL2096643 HALOPERIDOL LACTATE D2-like dopamine receptor inverse agonist 4 ISBN PubMed
CHEMBL3182733 PRAMIPEXOLE DIHYDROCHLORIDE D2-like dopamine receptor agonist 4 DailyMed
CHEMBL3989694 OLANZAPINE PAMOATE D2-like dopamine receptor antagonist 4 FDA
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

spacer
spacer