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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL2331043
Target Type PROTEIN FAMILY
Preferred Name Sodium channel alpha subunit
Synonyms HBSC II | HH1 | KIAA1356 | MED | NAC1 | NAC2 | NAC3 | NENA | Neuroendocrine sodium channel | PN1 | PN3 | PN5 | Peripheral nerve sodium channel 3 | Peripheral nerve sodium channel 5 | Peripheral sodium channel 1 | Putative voltage-gated sodium channel subunit alpha Nax | SCN1 | SCN10A | SCN11A | SCN12A | SCN1A | SCN2A | SCN2A1 | SCN2A2 | SCN3A | SCN4A | SCN5A | SCN6A | SCN7A | SCN8A | SCN9A | SNS2 | Sensory neuron sodium channel 2 | SkM1 | Sodium channel protein brain I subunit alpha | Sodium channel protein brain II subunit alpha | Sodium channel protein brain III subunit alpha | Sodium channel protein cardiac and skeletal muscle subunit alpha | Sodium channel protein cardiac muscle subunit alpha | Sodium channel protein skeletal muscle subunit alpha | Sodium channel protein type 1 subunit alpha | Sodium channel protein type 10 subunit alpha | Sodium channel protein type 11 subunit alpha | Sodium channel protein type 2 subunit alpha | Sodium channel protein type 3 subunit alpha | Sodium channel protein type 4 subunit alpha | Sodium channel protein type 5 subunit alpha | Sodium channel protein type 7 subunit alpha | Sodium channel protein type 8 subunit alpha | Sodium channel protein type 9 subunit alpha | Sodium channel protein type I subunit alpha | Sodium channel protein type II subunit alpha | Sodium channel protein type III subunit alpha | Sodium channel protein type IV subunit alpha | Sodium channel protein type IX subunit alpha | Sodium channel protein type V subunit alpha | Sodium channel protein type VII subunit alpha | Sodium channel protein type VIII subunit alpha | Sodium channel protein type X subunit alpha | Sodium channel protein type XI subunit alpha | Voltage-gated sodium channel subtype III | Voltage-gated sodium channel subunit alpha Nav1.1 | Voltage-gated sodium channel subunit alpha Nav1.2 | Voltage-gated sodium channel subunit alpha Nav1.3 | Voltage-gated sodium channel subunit alpha Nav1.4 | Voltage-gated sodium channel subunit alpha Nav1.5 | Voltage-gated sodium channel subunit alpha Nav1.6 | Voltage-gated sodium channel subunit alpha Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.8 | Voltage-gated sodium channel subunit alpha Nav1.9 | hNE-Na | hNaN | hPN3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 1 subunit alpha GROUP MEMBER P35498
Sodium channel protein type 2 subunit alpha GROUP MEMBER Q99250
Sodium channel protein type 3 subunit alpha GROUP MEMBER Q9NY46
Sodium channel protein type 4 subunit alpha GROUP MEMBER P35499
Sodium channel protein type 5 subunit alpha GROUP MEMBER Q14524
Sodium channel protein type 7 subunit alpha GROUP MEMBER Q01118
Sodium channel protein type 8 subunit alpha GROUP MEMBER Q9UQD0
Sodium channel protein type 9 subunit alpha GROUP MEMBER Q15858
Sodium channel protein type 10 subunit alpha GROUP MEMBER Q9Y5Y9
Sodium channel protein type 11 subunit alpha GROUP MEMBER Q9UI33

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL5451 Sodium channel protein type X alpha subunit SINGLE PROTEIN
CHEMBL1845 Sodium channel protein type I alpha subunit SINGLE PROTEIN
CHEMBL2096682 Sodium channel alpha subunits; brain (Types I, II, III) PROTEIN FAMILY
CHEMBL3585 Sodium channel protein type VII alpha subunit SINGLE PROTEIN
CHEMBL1980 Sodium channel protein type V alpha subunit SINGLE PROTEIN
CHEMBL4187 Sodium channel protein type II alpha subunit SINGLE PROTEIN
CHEMBL2072 Sodium channel protein type IV alpha subunit SINGLE PROTEIN
CHEMBL5163 Sodium channel protein type III alpha subunit SINGLE PROTEIN
CHEMBL4296 Sodium channel protein type IX alpha subunit SINGLE PROTEIN
CHEMBL5167 Sodium channel protein type XI alpha subunit SINGLE PROTEIN
CHEMBL5202 Sodium channel protein type VIII alpha subunit SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL16 PHENYTOIN Sodium channel alpha subunit blocker 4 FDA PubMed PubMed
CHEMBL79 LIDOCAINE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL108 CARBAMAZEPINE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL605 PROCAINAMIDE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 ISBN
CHEMBL698 TETRACAINE Sodium channel alpha subunit blocker 4 ISBN PubMed PubMed PubMed
CHEMBL741 LAMOTRIGINE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed PubMed
CHEMBL744 RILUZOLE Sodium channel alpha subunit blocker 4 DailyMed PubMed
CHEMBL750 ZONISAMIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed
CHEMBL856 PRIMIDONE Sodium channel alpha subunit blocker 4 ISBN
CHEMBL861 MEPHENYTOIN Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL918 PHENACEMIDE Sodium channel alpha subunit blocker 4 Expert
CHEMBL919 FOSPHENYTOIN SODIUM Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL58323 ERLOSAMIDE Sodium channel alpha subunit blocker 4 FDA PubMed
CHEMBL944 CHLOROPROCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 FDA PubMed
CHEMBL1068 OXCARBAZEPINE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL315985 ESLICARBAZEPINE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL87992 ESLICARBAZEPINE ACETATE Sodium channel alpha subunit blocker 4 FDA PubMed
CHEMBL1095 ETHOTOIN Sodium channel alpha subunit blocker 4 FDA PubMed PubMed
CHEMBL1194 PRILOCAINE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL220492 TOPIRAMATE Sodium channel alpha subunit blocker 4 DailyMed PubMed
CHEMBL1611 PHENYTOIN SODIUM Sodium channel alpha subunit blocker 4 FDA PubMed PubMed
CHEMBL1769 PROPOXYCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL1200334 MORICIZINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL1200341 INDECAINIDE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL1200395 ORPHENADRINE CITRATE Sodium channel alpha subunit blocker 4 PubMed
CHEMBL1200409 LIDOCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL1200437 QUINIDINE GLUCONATE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL1200440 MEPIVACAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL1200443 MERETHOXYLLINE PROCAINE Sodium channel alpha subunit blocker 4 DOI PubMed PubMed PubMed PubMed PubMed
CHEMBL1200464 PROPARACAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed
CHEMBL1200478 DYCLONINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL1200586 PRILOCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL1200597 ETIDOCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed PubMed
CHEMBL1200606 MEXILETINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL1200654 BENOXINATE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed
CHEMBL1200715 HEXYLCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 ISBN PubMed
CHEMBL1200773 TOCAINIDE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 ISBN
CHEMBL1200819 ARTICAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL1200841 PROCAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 ISBN PubMed PubMed PubMed
CHEMBL1201020 DISOPYRAMIDE PHOSPHATE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL1201022 PHENAZOPYRIDINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed PubMed
CHEMBL1201023 ORPHENADRINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL1201486 QUINIDINE POLYGALACTURONATE Sodium channel alpha subunit blocker 4 FDA
CHEMBL1201729 DRONEDARONE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 Expert FDA PubMed
CHEMBL1201754 RUFINAMIDE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL1255654 TETRACAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 ISBN PubMed PubMed PubMed
CHEMBL1889140 ROPIVACAINE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 DailyMed PubMed PubMed
CHEMBL2106155 ENCAINIDE HYDROCHLORIDE Sodium channel alpha subunit blocker 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL3184437 DICHLOROBENZYL ALCOHOL Sodium channel alpha subunit blocker 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL3707183 QUINIDINE SULFATE Sodium channel alpha subunit blocker 4 DailyMed
CHEMBL2107771 RALFINAMIDE Sodium channel alpha subunit blocker 3 Other PubMed
CHEMBL2107762 NERISPIRDINE Sodium channel alpha subunit blocker 2 Other PubMed
CHEMBL3545207 NW-3509 Sodium channel alpha subunit blocker 2 Other Other
CHEMBL29741 IRAMPANEL Sodium channel alpha subunit blocker 1 PubMed
CHEMBL3545209 NKTR-171 Sodium channel alpha subunit blocker 1 Other PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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