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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2331042
Target Type SINGLE PROTEIN
Preferred Name Potassium channel subfamily K member 18
Synonyms KCNK18 | Potassium channel subfamily K member 18 | TRESK | TRIK | TWIK-related individual potassium channel | TWIK-related spinal cord potassium channel
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > two-pore domain potassium channel

Target Components

Component Description Relationship Accession
Potassium channel subfamily K member 18 SINGLE PROTEIN Q7Z418

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL931 HALOTHANE Potassium channel subfamily K member 18 opener 4 PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL1256 ISOFLURANE Potassium channel subfamily K member 18 opener 4 PubMed PubMed PubMed
CHEMBL1257 ENFLURANE Potassium channel subfamily K member 18 opener 4 PubMed PubMed PubMed
CHEMBL1200694 SEVOFLURANE Potassium channel subfamily K member 18 opener 4 PubMed PubMed PubMed
CHEMBL1200733 DESFLURANE Potassium channel subfamily K member 18 opener 4 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186795
Ensembl ENSG00000186795
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005267 (potassium channel activity)
GO:0015269 (calcium-activated potassium channel activity)
GO:0015271 (outward rectifier potassium channel activity)
GO:0022841 (potassium ion leak channel activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0030322 (stabilization of membrane potential)
GO:0071435 (potassium ion export)
GO:0071467 (cellular response to pH)
GO:0071805 (potassium ion transmembrane transport)

Target Cross References - Protein

Human Protein Atlas ENSG00000186795
Open Targets ENSG00000186795
Pharos Q7Z418 (Tclin)
Reactome R-HSA-1299344 (TWIK-related spinal cord K+ channel (TRESK).)
R-HSA-5576886 (Phase 4 - resting membrane potential.)
UniProt Q5SQQ8 Q7Z418

Target Cross References - Domain

InterPro IPR003280 (2pore_dom_K_chnl.)
IPR013099 (K_chnl_dom.)
Pfam PF07885 (Ion_trans_2)
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