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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2327
Target Type SINGLE PROTEIN
Preferred Name Neurokinin 2 receptor
Synonyms NK-2 receptor | NK-2R | NK2R | NKNAR | Neurokinin A receptor | SKR | Substance-K receptor | TAC2R | TACR2 | Tachykinin receptor 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neurokinin receptor

Target Components

Component Description Relationship Accession
Substance-K receptor SINGLE PROTEIN P21452

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL266125 Ibodutant Neurokinin 2 receptor antagonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075073
Ensembl ENSG00000075073
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004995 (tachykinin receptor activity)
GO:0005515 (protein binding)
GO:0016497 (substance K receptor activity)
GO Biological Process GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007217 (tachykinin receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007588 (excretion)
GO:0014057 (positive regulation of acetylcholine secretion, neurotransmission)
GO:0014827 (intestine smooth muscle contraction)
GO:0033685 (negative regulation of luteinizing hormone secretion)
GO:0035106 (operant conditioning)
GO:0043117 (positive regulation of vascular permeability)
GO:0043270 (positive regulation of ion transport)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0051602 (response to electrical stimulus)
GO:0070459 (prolactin secretion)
GO:0070472 (regulation of uterine smooth muscle contraction)
GO:0070474 (positive regulation of uterine smooth muscle contraction)
Wikipedia Tachykinin_receptor_2

Target Cross References - Protein

canSAR P21452
Human Protein Atlas ENSG00000075073
IntAct P21452
Guide to Pharmacology 361
Open Targets ENSG00000075073
PharmGKB PA36303
Pharos P21452 (Tchem)
Reactome R-HSA-380095 (Tachykinin receptors bind tachykinins.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt A8K7I1 P21452 Q4QRI5 Q8NGQ8 Q9UDE6 Q9UDE7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000913 (NK2_rcpt.)
IPR001681 (Neurokn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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