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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2321615
Target Type SINGLE PROTEIN
Preferred Name Potassium channel subfamily K member 2
Synonyms KCNK2 | Outward rectifying potassium channel protein TREK-1 | Potassium channel subfamily K member 2 | TREK | TREK-1 K(+) channel subunit | TREK1 | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > two-pore domain potassium channel

Target Components

Component Description Relationship Accession
Potassium channel subfamily K member 2 SINGLE PROTEIN O95069

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL931 HALOTHANE Potassium channel subfamily K member 2 opener 4 PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL1256 ISOFLURANE Potassium channel subfamily K member 2 opener 4 PubMed PubMed PubMed
CHEMBL1257 ENFLURANE Potassium channel subfamily K member 2 opener 4 PubMed PubMed PubMed
CHEMBL1200694 SEVOFLURANE Potassium channel subfamily K member 2 opener 4 PubMed PubMed PubMed
CHEMBL1200733 DESFLURANE Potassium channel subfamily K member 2 opener 4 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000082482
Ensembl ENSG00000082482
GO Cellular Component GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0044305 (calyx of Held)
GO:0097449 (astrocyte projection)
GO Molecular Function GO:0005249 (voltage-gated potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0015271 (outward rectifier potassium channel activity)
GO:0019870 (potassium channel inhibitor activity)
GO:0022841 (potassium ion leak channel activity)
GO Biological Process GO:0003231 (cardiac ventricle development)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007613 (memory)
GO:0009612 (response to mechanical stimulus)
GO:0010942 (positive regulation of cell death)
GO:0030322 (stabilization of membrane potential)
GO:0042391 (regulation of membrane potential)
GO:0048678 (response to axon injury)
GO:0060044 (negative regulation of cardiac muscle cell proliferation)
GO:0071456 (cellular response to hypoxia)
GO:0071805 (potassium ion transmembrane transport)
GO:0090102 (cochlea development)
GO:1900039 (positive regulation of cellular response to hypoxia)
GO:2000279 (negative regulation of DNA biosynthetic process)

Target Cross References - Protein

Human Protein Atlas ENSG00000082482
Guide to Pharmacology 514
Open Targets ENSG00000082482
Pharos O95069 (Tclin)
Reactome R-HSA-1299503 (TWIK related potassium channel (TREK).)
R-HSA-5576886 (Phase 4 - resting membrane potential.)
UniProt A1Z1V3 A8K618 B2RCS4 B7ZL56 D3DTA5 O95069 Q5DP47 Q5DP48 Q9NRT2 Q9UNE3

Target Cross References - Domain

InterPro IPR003280 (2pore_dom_K_chnl.)
IPR003976 (2pore_dom_K_chnl_TREK.)
IPR013099 (K_chnl_dom.)
Pfam PF07885 (Ion_trans_2)

Target Cross References - Structure

PDBe 4TWK
CREDO 4TWK
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