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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2321614
Target Type SINGLE PROTEIN
Preferred Name Potassium channel subfamily K member 9
Synonyms Acid-sensitive potassium channel protein TASK-3 | KCNK9 | Potassium channel subfamily K member 9 | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > two-pore domain potassium channel

Target Components

Component Description Relationship Accession
Potassium channel subfamily K member 9 SINGLE PROTEIN Q9NPC2

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL931 HALOTHANE Potassium channel subfamily K member 9 opener 4 PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL1256 ISOFLURANE Potassium channel subfamily K member 9 opener 4 PubMed PubMed PubMed
CHEMBL1257 ENFLURANE Potassium channel subfamily K member 9 opener 4 PubMed PubMed PubMed
CHEMBL1200694 SEVOFLURANE Potassium channel subfamily K member 9 opener 4 PubMed PubMed PubMed
CHEMBL1200733 DESFLURANE Potassium channel subfamily K member 9 opener 4 PubMed PubMed PubMed PubMed
CHEMBL3989519 DOXAPRAM HYDROCHLORIDE Potassium channel subfamily K member 9 blocker 4 FDA PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169427
Ensembl ENSG00000169427
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005249 (voltage-gated potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0022841 (potassium ion leak channel activity)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0030322 (stabilization of membrane potential)
GO:0071804 (cellular potassium ion transport)
GO:0071805 (potassium ion transmembrane transport)

Target Cross References - Protein

Human Protein Atlas ENSG00000169427
Open Targets ENSG00000169427
Pharos Q9NPC2 (Tclin)
Reactome R-HSA-1299316 (TWIK-releated acid-sensitive K+ channel (TASK).)
R-HSA-5576886 (Phase 4 - resting membrane potential.)
UniProt Q2M290 Q540F2 Q9NPC2

Target Cross References - Domain

InterPro IPR003092 (2pore_dom_K_chnl_TASK.)
IPR003280 (2pore_dom_K_chnl.)
IPR005407 (KCNK9.)
IPR013099 (K_chnl_dom.)
Pfam PF07885 (Ion_trans_2)

Target Cross References - Structure

PDBe 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3UX0 4FR3
CREDO 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3UX0 4FR3
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