ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2321613
Target Type SINGLE PROTEIN
Preferred Name Potassium channel subfamily K member 3
Synonyms Acid-sensitive potassium channel protein TASK-1 | KCNK3 | Potassium channel subfamily K member 3 | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > two-pore domain potassium channel

Target Components

Component Description Relationship Accession
Potassium channel subfamily K member 3 SINGLE PROTEIN O14649

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL931 HALOTHANE Potassium channel subfamily K member 3 opener 4 PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL1256 ISOFLURANE Potassium channel subfamily K member 3 opener 4 PubMed PubMed PubMed
CHEMBL1257 ENFLURANE Potassium channel subfamily K member 3 opener 4 PubMed PubMed PubMed
CHEMBL1200694 SEVOFLURANE Potassium channel subfamily K member 3 opener 4 PubMed PubMed PubMed
CHEMBL1200733 DESFLURANE Potassium channel subfamily K member 3 opener 4 PubMed PubMed PubMed PubMed
CHEMBL3989519 DOXAPRAM HYDROCHLORIDE Potassium channel subfamily K member 3 blocker 4 FDA PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171303
Ensembl ENSG00000171303
GO Cellular Component GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005252 (open rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008083 (growth factor activity)
GO:0022841 (potassium ion leak channel activity)
GO:0042803 (protein homodimerization activity)
GO:0044548 (S100 protein binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007420 (brain development)
GO:0010469 (regulation of receptor activity)
GO:0030322 (stabilization of membrane potential)
GO:0034220 (ion transmembrane transport)
GO:0042493 (response to drug)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0061337 (cardiac conduction)
GO:0071294 (cellular response to zinc ion)
GO:0071456 (cellular response to hypoxia)
GO:0071805 (potassium ion transmembrane transport)
GO:0090102 (cochlea development)

Target Cross References - Protein

Human Protein Atlas ENSG00000171303
IntAct O14649
Guide to Pharmacology 515
Open Targets ENSG00000171303
Pharos O14649 (Tclin)
Reactome R-HSA-1299316 (TWIK-releated acid-sensitive K+ channel (TASK).)
R-HSA-5576886 (Phase 4 - resting membrane potential.)
UniProt O14649 Q53SU2

Target Cross References - Domain

InterPro IPR003092 (2pore_dom_K_chnl_TASK.)
IPR003280 (2pore_dom_K_chnl.)
IPR005406 (KCNK3.)
IPR013099 (K_chnl_dom.)
IPR022341 (IGF-I.)
Pfam PF07885 (Ion_trans_2)
spacer
spacer