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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL232
Preferred Name Alpha-1b adrenergic receptor
Synonyms ADRA1B | Alpha-1B adrenergic receptor | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1B adrenergic receptor SINGLE PROTEIN P35368

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096676 Adrenergic receptors; alpha-1 A & B SELECTIVITY GROUP
CHEMBL2094251 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170214
Ensembl ENSG00000170214
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0031965 (nuclear membrane)
GO:0005829 (cytosol)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004937 (alpha1-adrenergic receptor activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001975 (response to amphetamine)
GO:0008542 (visual learning)
GO:0045907 (positive regulation of vasoconstriction)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0001974 (blood vessel remodeling)
GO:0001996 (positive regulation of heart rate by epinephrine-norepinephrine)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007512 (adult heart development)
GO:0042593 (glucose homeostasis)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0035265 (organ growth)
GO:0035556 (intracellular signal transduction)
GO:0045819 (positive regulation of glycogen catabolic process)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0001987 (vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure)
GO:0001997 (positive regulation of the force of heart contraction by epinephrine-norepinephrine)
GO:0043278 (response to morphine)
GO:0043410 (positive regulation of MAPK cascade)
GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0007626 (locomotory behavior)
GO:0008283 (cell proliferation)
GO:0016049 (cell growth)
GO:0045818 (negative regulation of glycogen catabolic process)
GO:0007275 (multicellular organismal development)
GO:0048148 (behavioral response to cocaine)
Wikipedia Alpha-1B_adrenergic_receptor

Target Cross References - Protein

canSAR P35368
Human Protein Atlas ENSG00000170214
IntAct P35368
Guide to Pharmacology 23 (Alpha;1B-adrenoceptor)
PharmGKB PA33
UniProt P35368 B0LPE1

Target Cross References - Domain

InterPro IPR017452 (GPCR_Rhodpsn_7TM.)
IPR001115 (ADRA1B_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR002233 (ADR_fam.)
Pfam PF00001 (7tm_1)