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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2319
Target Type SINGLE PROTEIN
Preferred Name Kallikrein 1
Synonyms KLK1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Kallikrein-1 SINGLE PROTEIN P06870

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167748
Ensembl ENSG00000167748
GO Cellular Component GO:0005634 (nucleus)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
Wikipedia KLK1

Target Cross References - Protein

canSAR P06870
Human Protein Atlas ENSG00000167748
Guide to Pharmacology 2865
Open Targets ENSG00000167748
PharmGKB PA224
Reactome R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
UniProt P06870 Q66US9 Q86U61 Q8TCV8 Q9BS53 Q9NQU4 Q9UD19 Q9UMJ1

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1SPJ
CREDO 1SPJ
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